Discriminative stimulus properties of /+/-oxaprotiline in rat

• Autorzy: Malgorzata Filip , Ewa Chojnacka-Wojcik , Edmund Przegalinski
• Języki publikacji: EN

Abstrakty

EN

Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.

Słowa kluczowe

EN

ANTIDEPRESSANT DRUG; DRUG DISCRIMINATION

• Czasopismo: Polish Journal of Pharmacology
• Rocznik: 1993
• Tom: 45
• Numer: 2
• Strony: 151-156

Twórcy

autor

Malgorzata Filip

autor

Ewa Chojnacka-Wojcik

autor

Edmund Przegalinski

• Typ dokumentu: article