Control of immune responses by immunoregulatory T cells

• Autorzy: G. Rudge , P.A. Gleeson , Driel J.R. van_
• Języki publikacji: EN

Abstrakty

EN

Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4+ regulatory T cells that constitutively express CD25 (CD25+ Treg). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25+ Treg, and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25+ Treg in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.

Słowa kluczowe

EN

IMMUNOREGULATION; REGULATORY T CELL; TUMOR IMMUNITY

• Czasopismo: Archivum Immunologiae et Therapiae Experimentalis
• Rocznik: 2006
• Tom: 54
• Numer: 6
• Strony: 381-391

Twórcy

autor

G. Rudge

autor

P.A. Gleeson

autor

Driel J.R. van_

• Typ dokumentu: REVIEW
• Bibliografia: Ian R. van Driel, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia