Warianty tytułu
Języki publikacji
Abstrakty
Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4+ regulatory T cells that constitutively express CD25 (CD25+ Treg). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25+ Treg, and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25+ Treg in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.
Słowa kluczowe
Rocznik
Tom
Numer
Strony
381-391
Opis fizyczny
Twórcy
Bibliografia
Typ dokumentu
REVIEW
Bibliografia
Ian R. van Driel, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.element-from-psjc-98c7e1e4-2408-3679-8436-88949106ba6a