Human cord blood cells can differentiate into retinal nerve cells

• Autorzy: N. Koike-Kiriyama , Y. Adachi , K. Minamino , M. Iwasaki , K. Nakano , Y. Koike , H. Yamada , H. Mukaide , A. Shigematsu , T. Mizokami , M. Matsumura , S. Ikehara
• Języki publikacji: EN

Abstrakty

EN

Retinal degeneration and dystrophy are the major causes of blindness in the developed world. It has been reported that human cord blood cells (HCBCs) can differentiate into neuron-like cells in vitro. We have recently demonstrated that bone marrow cells (BMCs) of both mice and rats can differentiate into retinal nerve cells (RNCs). In the present study, we show the differentiation capacity of HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after the transplantation, some of the transplanted cells expressed human nestin, human MAP2, human neuron specific enolase (NSE), beta-III tubulin and also rhodopsin. These results indicate that HCBCs can differentiate into RNCs and suggest that our new strategy could be used for the regeneration of retinal nerve cells in degenerative or dystrophic diseases.

Słowa kluczowe

EN

CORD BLOOD; DYSTROPHY; HUMAN; REGENERATION; RETINAL DEGENERATION; STEM CELL

• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2007
• Tom: 67
• Numer: 4
• Strony: 359-365

Twórcy

autor

N. Koike-Kiriyama

autor

Y. Adachi

autor

K. Minamino

autor

M. Iwasaki

autor

K. Nakano

autor

Y. Koike

autor

H. Yamada

autor

H. Mukaide

autor

A. Shigematsu

autor

T. Mizokami

autor

M. Matsumura

autor

S. Ikehara

• Typ dokumentu: ARTICLE
• Bibliografia: S. Ikehara, First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka 570-8506, Japan