Prospects for development of new antimycobacterial drugs, with special reference to a new benzoxazinorifamycin, KRM-1648

• Autorzy: H. Tomioka
• Języki publikacji: EN

Abstrakty

EN

In this article, I have thoroughly reviewed the status of development of new antimycobacterial drugs, in particular, rifamycin derivatives (rifabutin, rifapentine, and a new benzoxazinorifamycin, KRM-1648), fluoroquinolones (ciprofloxacin, ofloxacin, sparfloxacin, levofloxacin, gatifloxacin, sitafloxacin, moxifloxacin, and others), new macrolides (clarithromycin, azithromycin, roxithromycin), and others. In this review, I have mainly described the in vitro and in vivo activities of these drugs against Mycobacterium tuberculosis and atypical mycobacteria, especially Mycobacterium avium complex. In addition, therapeutic efficacy of these drugs in cases of clinical treatment of mycobacterial infections have also been briefly mentioned.

Słowa kluczowe

EN

ANTIMYCOBACTERIAL DRUG; INFECTION; MYCOBACTERIA; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS

• Czasopismo: Archivum Immunologiae et Therapiae Experimentalis
• Rocznik: 2000
• Tom: 48
• Numer: 3
• Strony: 183-188

Twórcy

autor

H. Tomioka

• Typ dokumentu: REVIEW
• Bibliografia: H.Tomioka, Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane 693-8501, Japan