Dysregulation of calcium in Alzheimer's disease

• Autorzy: M. Brzyska , E. Danek
• Języki publikacji: EN

Abstrakty

EN

Multiple efforts has underlined importance of calcium dependent cellular processes in the biochemical characterisation of Alzheimer?s disease (AD), suggesting that abnormalities in calcium (Ca2+) homeostasis might be involved in the pathophysiology of the disease. Studies of the pathogenic mutations in presenilins 1 and 2 (PS1 and PS2) and amyloid precursor protein (APP) responsible for early onset familial AD have estabilished central roles for perturbed cellular Ca2+ homeostasis. Studies of apolipoprotein E (ApoE) neurotoxic effects in AD confirmed involvement of Ca2+-mediated mechanisms. Futher consequences of Ca2+ alterations in AD underline the importance of the ER and mitochondria as the regulatory sites involved in the pathogenesis of neuronal degeneration. Alterations of Ca2+ homeostasis include cells from peripheral tissues, including lymphocytes and fibroblasts from AD donors.

Słowa kluczowe

EN

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; CALCIUM; MITOCHONDRIA; PERIPHERAL CELL

• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2003
• Tom: 63
• Numer: 3
• Strony: 171-183

Twórcy

autor

M. Brzyska

autor

E. Danek

• Typ dokumentu: article