Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice

• Autorzy: J. Marti , M.C. Santa-Cruz , V. Molina , R. Serra , S.A. Bayer , B. Ghetti , J.P. Hervas
• Języki publikacji: EN

Abstrakty

EN

Vulnerability of midbrain dopaminergic (DA) neurons in the weaver mouse was studied at postnatal (P) days 8 and 90, in chosen coronal levels throughout the anteroposterior (AP) extent of the substantia nigra pars compacta (SNc). Wild-type (+/+) and homozygous weaver (wv/wv) mice used were the offspring of pregnant dams injected in several cases with tritiated thymidine on embryonic days 11-15. DA neurons were identified for their tyrosine hydroxylase immunoreactivity. Data reveal that at P8, the frequency of both +/+ and wv/wv late-generated DA cells increases from rostral to caudal SNc. No apparent DA-cell loss was observed at P8 in the mutant genotype, irrespective of the AP level considered. However, throughout the AP, there was a significant reduction in the number of these neurons at any level in 90-day-old weavers. Comparison of P8 and P90 +/+ SNc suggests that cell death is not a major aspect in the developmental regulation of normal DA neurons, although numerical cell depletion in the postnatal development of weaver SNc probably results from the amplification of a basal cell-death process, which affected all the coronal levels studied.

Słowa kluczowe

EN

DOPAMINERGIC NEURON; TYROSINE HYDROXYLASE; WEAVER MOUSE

• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 2
• Strony: 198-206

Twórcy

autor

J. Marti

autor

M.C. Santa-Cruz

autor

V. Molina

autor

R. Serra

autor

S.A. Bayer

autor

B. Ghetti

autor

J.P. Hervas

• Typ dokumentu: ARTICLE
• Bibliografia: Joaquin Marti, Faculty of Biosciences, Department of Cellular Biology, Physiology and Immunology, Citology and Histology Unit, Autonomous University of Barcelona, Barcelona, Spain