Promoting phorbol ester-TPA enhances migration of C3H 10TI/2ells.The role of protein kinase C and its relation to carcinogenesis

• Autorzy: P. Janik , B. Szaniawska , D. Kowalczyk , K. Maternicka
• Języki publikacji: EN

Abstrakty

EN

Treatment of 10T1/2 cells with promoting phorbol ester drasticly enhanced migration studied fibroblasts in a serum-supplemented medium.The same cells when exposed to ionomycin or TPA in a serum-free medium did not show any migration.The addition of 1% of serum induced spontaneous and TPA stimulated migration.Also EGF and PDGE separatly or together induced the migration of 10T1/2 cells.Parallel studies of protein kinase C documented low enzymatic activity after treatment with TPA, whereas transcripts of PKC were shown independently of TPA treatment.

Słowa kluczowe

EN

CELL MIGRATION; PHORBOL ESTER; PROTEIN KINASE C

• Czasopismo: Folia Biologica
• Rocznik: 1995
• Tom: 43
• Numer: 3-4
• Strony: 83-87

Twórcy

autor

P. Janik

autor

B. Szaniawska

autor

D. Kowalczyk

autor

K. Maternicka

• Typ dokumentu: article
• Bibliografia: P.Janik