Warianty tytułu
Języki publikacji
Abstrakty
The etiology of Crohn's disease (CD) is still poorly understood, but recent advances have highlighted the importance of the innate immune system and the critical relationship between the gut flora and the intestinal mucosa. Several combinations of genetic factors predisposing to CD have been described, with the most significant replicable associations including genes for intracellular receptors of bacterial cell walls (NOD2/CARD15) and for bacterial clearance and antigen processing via autophagy (ATG16L1 and IRGM). One theoretical link between susceptibility genes NOD2/CARD15, ATG16L1, and IRGM is that CD is primarily induced by the presence of a dysfunctional immunological response to persistent infection by intracellular bacterial pathogens such as Mycobacterium avium subspecies paratuberculosis or adherent-invasive Escherichia coli, both first-rank candidates on the basis of host genetic susceptibility, which concerns impaired functions in the defense against intracellular bacteria.
Słowa kluczowe
Rocznik
Tom
Numer
Strony
237-244
Opis fizyczny
Twórcy
autor
autor
Bibliografia
Typ dokumentu
REVIEW
Bibliografia
Arlette Darfeuille-Michaud, Pathogenie Bactrienne Intestinale, Laboratoire de Bacteriologie, CBRV, 28 place Henri Dunant, 63000 Clermont-Ferrand, France
Identyfikatory
Identyfikator YADDA
bwmeta1.element.element-from-psjc-084dbec3-b9dd-341e-8ff1-2b600b4e4fe2