The mitochondria mediate the induction of NOX1 gene expression by aldosterone in an ATF-1-dependent manner

• Autorzy: Fu Y. , Shi G. , Wu Y. , Kawai Y. , Qing T. , Yue L. , Xia Q. , Miyamori I. , Fan C.
• Języki publikacji: EN

Abstrakty

EN

High aldosterone (Ald) levels can induce hypertrophy of vascular smooth muscle cells (VSMCs), which carries high risks of heart failure. A previous study showed that Ald induces hypertrophy of VSMCs by up-regulating NOX1, a catalytic subunit of NADPH oxidase that produces superoxides. However, the precise mechanism remains unknown. Diphenylene iodonium (DPI) is known as an inhibitor of complex I in the mitochondrial respiratory chain, and it was also found to almost completely suppress the induction of NOX1 mRNA and the phosphorylation of activating transcription factor (ATF-1) by PGF2α or PDGF in a rat VSMC cell line. In this study, we found that the Ald-induced phosphorylation of ATF-1 and NOX1 expression was significantly suppressed by DPI. Silencing of ATF-1 gene expression attenuated the induction of NOX1 mRNA expression, and over-expression of ATF-1 restored Ald-induced NOX1 expression. On the basis of this data, we show that the mitochondria mediate aldosterone-induced NOX1 gene expression in an ATF-1-dependent manner.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2011
• Tom: 16
• Numer: 2
• Opis fizyczny: p.226-235,fig.ref.

Twórcy

autor

Fu Y.

• Department of Nephrology, West China Hospital of Sichuan University, Guoxue Lane 37, WuHou Zone, Chengdu, 610041, China

autor

Shi G.

autor

Wu Y.

autor

Kawai Y.

autor

Qing T.

autor

Yue L.

autor

Xia Q.

autor

Miyamori I.

autor

Fan C.

Bibliografia

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Uwagi

PL

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