Identification and simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice by LC-MS/MS

• Autorzy: Xie, J. , Zhang, Y. , Wang, W. , Hou, J.
• Języki publikacji: EN

Abstrakty

EN

A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice. An Eclipse Plus C18 column (I.D. 4.6 × 100 mm, 3.5 μm particle size; Agilent) was used in the analysis. Electrospray ionization (ESI)-tandem interface in the negative mode was performed, and multiple reaction monitoring (MRM) was employed with the precursor multiple reaction monitoring production combination for the determination of six analytes. The average recoveries ranged from 98.30% to 100.13% with relative standard deviations (RSDs) ≤ 1.95%, and limits of detection (LODs) ranged from 2.1 to 3.6 pg. The applicability of this analytical approach was confirmed by the successful analysis of six samples. The results indicated that the established method was validated, sensitive, and reliable for the determination of six analytes in licorice.

Słowa kluczowe

EN

licorice; LC-MS/MS; simultaneous analysis; glycyrrhizin; liquiritin; licochalcone A

• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 3
• Strony: 507--516
• Opis fizyczny: Bibliogr. 22 poz., rys., tab.

Twórcy

autor

Xie, J.

• Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China
• Ministry of Education Engineering Research Center of GAP Beijing 100102 China

autor

Zhang, Y.

• Tianjin University of Commerce Department of Pharmaceutical Engineering Tianjin 300134 China

autor

Wang, W.

• Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China,
• Ministry of Education Engineering Research Center of GAP Beijing 100102 China

autor

Hou, J.

• Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing 100102 China
• Ministry of Education Engineering Research Center of GAP Beijing 100102 China

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