Drug-device systems based on biodegradable metals for bone applications: Potential, development and challenges

• Autorzy: Md Yusop, Abdul Hakim , Sarian, Murni Nazira , Szali Januddi, Fatihhi , Nur, Hadi
• Języki publikacji: EN

Abstrakty

EN

Drug-device systems based on biodegradable metals have been of great interest in the last decade due to their local-release regime and the ability of the biodegradable metals to degrade in the physiological environment facilitating tissue growth and gradual load transfer. The biodegradability of the biodegradable metals provides a promising medium that might enable other materials - such as drugs, bioactive materials and therapeutic agents - to be incorporated into the degradable metals to act as a drug-device system that would locally release the drugs or therapeutic agents onto the healing tissue. In comparison to systemic drug delivery, the locally released drug-device system makes the dose control over a specific targeted tissue more efficient and reduces the side effects on non-targeted tissues. This review outlines the current state of development of the biodegradable metals-based drug-device system and focuses in-depth on the potential interactions between the drugs, degradable metallic surfaces, drug carriers, ions and proteins inside the body fluids, which can be a challenge to producing a highly efficient drug-device system.

Słowa kluczowe

PL

metal biodegradowalny; wyzwalacz lokalny; interakcje fizyczne białka; interakcje chemiczne białka

EN

drug device; biodegradable metal; local release; physical interactions proteins; chemical interactions proteins

• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2023
• Tom: Vol. 43, no. 1
• Strony: 42--57
• Opis fizyczny: Bibliogr. 93 poz., rys., tab., wykr.

Twórcy

autor

Md Yusop, Abdul Hakim

• Materials Research & Consultancy Group (MRCG), Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia,
• Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia
• Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bharu, Johor, Malaysia

autor

Sarian, Murni Nazira

• Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bandar Baru Bangi, Selangor, Malaysia

autor

Szali Januddi, Fatihhi

• Advanced Facilities Engineering Technology Research Cluster (AFET), Plant Engineering Technology (PETech) Section, Universiti Kuala Lumpur Malaysian Institute of Industrial Technology, Masai, Johor, Malaysia,

autor

Nur, Hadi

• Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia,
• Center of Advanced Materials for Renewable Energy (CAMRY), Universitas Negeri Malang, Malang, Indonesia

Bibliografia

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)

Identyfikatory

DOI

10.1016/j.bbe.2022.11.002