Warianty tytułu
Flash therapy : a new miracle in cancer radiation therapy malicious?
Języki publikacji
Abstrakty
Wydaje się, że nowatorska metoda radioterapii (RT) w leczeniu onkologicznym, z wykorzystaniem promieniowania o wysokiej mocy dawki (FLASH), pozwala znacząco zmniejszyć toksyczność wywołaną promieniowaniem w zdrowych tkankach, jednocześnie wykazując wysoką skuteczność w zabijaniu komórek nowotworowych. Dotychczas przeprowadzono wiele badań przedklinicznych oraz jedno badanie kliniczne, które wykazały korzyści tej metody w porównaniu z metodą konwencjonalną. Dalsze prowadzenie badań napotyka jednak na ograniczony dostęp do urządzeń generujących stabilną i powtarzalną wiązkę promieniowania o ultrawysokiej mocy dawki. Niniejsza praca prezentuje obecny stan wiedzy na temat badań przedklinicznych, hipotez mechanizmu efektu FLASH w komórkach oraz koniecznych udoskonaleń urządzeń generujących wiązkę, tak aby było możliwe osiągnięcie wysokiej mocy dawki przy spełnieniu jednocześnie wymagań terapii.
The novel method of radiation therapy in cancer treatment using high dose radiation (FLASH) appears to be able to significantly reduce radiation-induced toxicity in healthy tissues, while demonstrating high efficiency in killing cancer cells. So far, many preclinical studies and one clinical trial have been carried out, which showed significant advantages of this method compared to the conventional method. However, further research is faced with limited access to devices generating a stable and repeatable beam of ultra-high dose radiation. This paper presents the current state of knowledge on preclinical research, the hypotheses of the FLASH effect mechanism in cells and the necessary improvements to the beam generating devices, so that it is possible to achieve a high dose rate while meeting the requirements of the therapy.
Rocznik
Tom
Strony
27--30
Opis fizyczny
Bibliogr. 26 poz.
Twórcy
autor
- Narodowe Centrum Badań Jądrowych, Otwock
autor
- Narodowe Centrum Badań Jądrowych, Otwock
autor
- Narodowe Centrum Badań Jądrowych, Otwock
Bibliografia
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- [15] Adrian G, Konradsson E, Lempart M, Bäck S, Ceberg C, Petersson K. The FLASH effect depends on oxygen concentration. Br J Radiol. concentration. 2019.
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- [18] Girdhani S, Abel E, Katsis A, Rodriquez A, Senapati S, KuVillanueva A, et al. Abstract LB-280: FLASH: A novel paradigm changing tumor irradiation platform that enhances therapeutic ratio by reducing normal tissue toxicity and activating immune pathways. Cancer Res. 79(13 Suppl):LB-280. 2019.
- [19] Rama N, Saha T, Shukla S, Goda C, Milewski D, Mascia AE, et al. Improved tumor control through t-cell infiltration modulated by ultra-high dose rate proton FLASH using a clinical pencil beam scanning proton system. Int J Radiat Oncol Biol Phys. 105: S164-5. 2019.
- [20] Montay-Gruel P, Meziani L, Yakkala C, Vozenin MC. Expanding the therapeutic index of radiation therapy by normal tissue protection. Br J Radiol. 2018.
- [21] Favaudon V., Caplier, L., Monceau, V., Pouzoulet, F., Sayarath, M., Fouillade, C., Poupon, M. F., Brito, I., Hupé, P., Bourhis, J., Hall, J., Fontaine, J. J., & Vozenin, M. C. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Science translational medicine, 6(245). 2014.
- [22] Jean Bourhis, Wendy Jeanneret Sozzi, Patrik Gonçalves Jorge, Olivier Gaide, Claude Bailat, Fréderic Duclos, David Patin, Mahmut Ozsahin, François Bochud, Jean-François Germond, Raphaël Moeckli, Marie-Catherine Vozenin,. Treatment of a first patient with FLASH-radiotherapy. Radiotherapy and Oncology, Volume 139. 2019.
- [23] Vozenin M. C., De Fornel, P., Petersson, K., Favaudon, V., Jaccard, M., Germond, J. F., Petit, B., Burki, M., Ferrand, G., Patin, D., Bouchaab, H., Ozsahin, M., Bochud, F., Bailat, C., Devauchelle, P., & Bourhis, J. The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(1), 35-42. 2019.
- [24] Felici Giuseppe & Barca, Patrizio & Barone, Salvatore & Bortoli, Eleonora & Borgheresi, Rita & De Stefano, Silvia & Francesco, Massimo & Grasso, Luigi & Linsalata, Stefania & Marfisi, Daniela & Pacitti, Matteo & Di Martino, Fabio. Transforming an IORT Linac Into a FLASH Research Machine: Procedure and Dosimetric Characterization. Frontiers in Physics. 8. 374. 2020.
- [25] Moeckli R., Gonçalves Jorge, P., Grilj, V., Oesterle, R., Cherbuin, N., Bourhis, J., Vozenin, M. C., Germond, J. F., Bochud, F., & Bailat, C. Commissioning of an ultra-high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols. Medical physics, 48(6), 3134-3142. 2021.
- [26] Pierre Montay-Gruel, Kristoffer Petersson, Maud Jaccard, Gaël Boivin, Jean-François Germond, Benoit Petit, Raphaël Doenlen, Vincent Favaudon, François Bochud, Claude Bailat, Jean Bourhis, Marie-Catherine Vozenin,. Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s. Radiotherapy and Oncology, Volume 124, Issue 3. 2017.
Uwagi
Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.baztech-eac22d2e-4bcc-4fd0-9b72-2e12e11bca42