A comparative analysis of coronary bypass implants: Experimental and fluid-structure interaction analysis

• Autorzy: Changizi, Shirin , Afrasiabian, Nima , Rassoli, Aisa , Fatouraee, Nasser , Ahmadi Tafti, Seyed Hossein
• Języki publikacji: EN

Abstrakty

EN

Bypass surgery is a commonly employed method for treating coronary artery diseases, involving the use of grafts to bypass occluded arteries. However, graft occlusion remains a concern due to mechanical disparities between the grafts and native arteries. This study aims to compare the mechanical properties of three frequently used grafts in coronary bypass surgeries: human saphenous veins, mammary arteries, and radial arteries. Stress-relaxation tests were conducted on samples obtained from these vessels, and their mechanical properties were characterized. The stress-strain curves of each sample were fitted using the quasi-linear viscoelastic (QLV) model, with MATLAB software used to extract the model’s constants. Additionally, fluid-structure simulations were performed employing the extracted viscoelastic mechanical properties of the vessels. The analysis revealed that the saphenous vein exhibited the highest elastic coefficient (0.5247) and non-linearity coefficient (0.8135) among the studied grafts. The mammary artery demonstrated nearly seven times greater viscoelasticity compared to the other graft options. Furthermore, the examination of shear stress distribution indicated lower shear stress regions in the radial and mammary artery specimens compared to the saphenous specimens. Notably, the lower wall of the host artery exhibited the greatest oscillatory shear index (OSI), with the radial specimen displaying the highest oscillation in this region compared to the other two specimens. The mechanical characterization results presented in this study hold potential applications in pathogenic and clinical investigations of heart diseases, aiding in the development of appropriate treatment approaches.

Słowa kluczowe

PL

bypass wieńcowy; model lepkosprężysty; współczynnik sprężystości

EN

coronary bypass surgery; mechanical properties; viscoelastic model; QLV equation; elastic coefficient; nonlinearity coefficient; fluid structure interaction

• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2024
• Tom: Vol. 44, no. 2
• Strony: 393--401
• Opis fizyczny: Bibliogr. 34 poz., rys., tab., wykr.

Twórcy

autor

Changizi, Shirin

• Biomedical Department, Florida Institute of Technology, Melbourne, FL, USA

autor

Afrasiabian, Nima

• Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

autor

Rassoli, Aisa

• Faculty of Mechanical Engineering, K.N. Toosi University of Technology, P.O. Box: 19395-19999, Tehran 1991943344, Iran,

autor

Fatouraee, Nasser

• Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

autor

Ahmadi Tafti, Seyed Hossein

• Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Bibliografia

• [1] Alderson H, Zamir M. Smaller, stiffer coronary bypass can moderate or reverse the adverse effects of wave reflections. J Biomech 2001;34(11):1455-62.
• [2] Changizi S, Sameti M, Bazemore G, Chen H, Bashur CA. Epsin mimetic UPI peptide delivery strategies to improve endothelization of vascular grafts. Macromol Biosci 2023:2300073.
• [3] Rossmann JS. Elastomechanical properties of bovine veins. J Mech Behav Biomed Mater 2010;3(2):210-5.
• [4] Khot UN, Friedman DT, Pettersson G, Smedira NG, Li J, Ellis SG. Radial artery bypass grafts have an increased occurrence of angiographically severe stenosis and occlusion compared with left internal mammary arteries and saphenous vein grafts. Circulation 2004;109(17):2086-91.
• [5] Desai ND, Cohen EA, Naylor CD, Fremes SE. A randomized comparison of radial-artery and saphenous-vein coronary bypass grafts. N Engl J Med 2004;351(22): 2302-9.
• [6] Baikoussis NG, Papakonstantinou NA, Apostolakis E. Radial artery as graft for coronary artery bypass surgery: advantages and disadvantages for its usage focused on structural and biological characteristics. J Cardiol 2014;63(5):321-8.
• [7] Van Andel CJ, Pistecky PV, Borst C. Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors. Ann Thorac Surg 2003; 76(1):58-64.
• [8] Silver FH, Snowhill PB, Foran DJ. Mechanical behavior of vessel wall: a comparative study of aorta, vena cava, and carotid artery. Ann Biomed Eng 2003; 31:793-803.
• [9] Wicker BK, Hutchens HP, Wu Q, Yeh AT, Humphrey JD. Normal basilar artery structure and biaxial mechanical behaviour. Comput Methods Biomech Biomed Eng 2008;11(5):539-51.
• [10] Chamiot-Clerc P, Copie X, Renaud J-F, Safar M, Girerd X. Comparative reactivity and mechanical properties of human isolated internal mammary and radial arteries. Cardiovasc Res 1998;37(3):811-9.
• [11] Mavrilas D, Tsapikouni T, Mikroulis D, Bitzikas G, Didilis V, Tsakiridis K, et al. Dynamic mechanical properties of arterial and venous grafts used in coronary bypass surgery. Journal of Mechanics in Medicine and Biology 2002;2(03n04): 329-37.
• [12] Rassoli A, Fatouraee N, Shafigh M. Uniaxial and biaxial mechanical properties of the human saphenous vein. Biomed Eng: Appl, Basis Commun 2015;27(05): 1550050.
• [13] Zeng D, Ding Z, Friedman MH, Ethier CR. Effects of cardiac motion on right coronary artery hemodynamics. Ann Biomed Eng 2003;31:420-9.
• [14] Torii R, Wood NB, Hadjiloizou N, Dowsey AW, Wright AR, Hughes AD, et al. Fluid-structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms. Commun Numer Methods Eng 2009;25(5):565-80.
• [15] Fujiwara T, Liang F, Tsubota K, Sugawara M, Fan Y, Liu H. Effects of vessel dynamics and compliance on human right coronary artery hemodynamics with/without stenosis. J Biomech Sci Eng 2015;10(2):15.
• [16] Dutra RF, Zinani FSF, Rocha LAO, Biserni C. Effect of non-Newtonian fluid rheology on an arterial bypass graft: A numerical investigation guided by constructal design. Comput Methods Programs Biomed 2021;201:105944.
• [17] Frauenfelder T, Boutsianis E, Schertler T, Husmann L, Leschka S, Poulikakos D, et al. Flow and wall shear stress in end-to-side and side-to-side anastomosis of venous coronary artery bypass grafts. Biomed Eng Online 2007;6:1-13.
• [18] Totorean AF, Bernad SI, Hudrea IC, Susan-Resiga RF. Competitive flow and anastomosis angle influence on bypass hemodynamics in unsteady flow conditions. AIP Conf Proc 2017;1863(1):30013.
• [19] Alizadehghobadi S, Biglari H, Niroomand-Oscuii H, Matin MH. Numerical study of hemodynamics in a complete coronary bypass with venous and arterial grafts and different degrees of stenosis. Comput Methods Biomech Biomed Eng 2021;24(8): 883-96.
• [20] Fung Y. Biomechanics: mechanical properties of living tissues. Springer Science & Business Media; 2013.
• [21] Gauvin R, Guillemette M, Galbraith T, Bourget J-M, Larouche D, Marcoux H, et al. Mechanical properties of tissue-engineered vascular constructs produced using arterial or venous cells. Tissue Eng A 2011;17(15-16):2049-59.
• [22] Rassoli A, Fatouraee N, Guidoin R, Zhang Z, Ravaghi S. A comparative study of different tissue materials for bioprosthetic aortic valves using experimental assays and finite element analysis. Comput Methods Programs Biomed 2022;220:106813.
• [23] Abramowitch SD, Woo S-L-Y. An improved method to analyze the stress relaxation of ligaments following a finite ramp time based on the quasi-linear viscoelastic theory. J Biomech Eng 2004;126(1):92-7.
• [24] Castile RM, Skelley NW, Babaei B, Brophy RH, Lake SP. Microstructural properties and mechanics vary between bundles of the human anterior cruciate ligament during stress-relaxation. J Biomech 2016;49(1):87-93.
• [25] Uus, A. Patient-specific blood flow modelling in diagnosis of coronary artery disease. Unpublished Doctoral Thesis, City University London) This Is the Accepted Version of the Paper. This Version of the Publication May Differ from the Final Published Version, 2016.
• [26] Kabinejadian F, Ghista DN. Compliant model of a coupled sequential coronary arterial bypass graft: Effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution. Med Eng Phys 2012;34(7):860-72.
• [27] Karimi A, Shojaei A, Razaghi R. Viscoelastic mechanical measurement of the healthy and atherosclerotic human coronary arteries using DIC technique. Artery Res 2017;18:14-21.
• [28] Sankaranarayanan M, Chua LP, Ghista DN, Tan YS. Computational model of blood flow in the aorto-coronary bypass graft. Biomed Eng Online 2005;4(1):1-13.
• [29] Kabinejadian F, Ghista DN, Su B, Nezhadian MK, Chua LP, Yeo JH, et al. In vitro measurements of velocity and wall shear stress in a novel sequential anastomotic graft design model under pulsatile flow conditions. Med Eng Phys 2014;36(10): 1233-45.
• [30] Wuyts FL, Vanhuyse VJ, Langewouters GJ, Decraemer WF, Raman ER, Buyle S. Elastic properties of human aortas in relation to age and atherosclerosis: a structural model. Phys Med Biol 1995;40(10):1577.
• [31] Karimi A, Navidbakhsh M, Alizadeh M, Shojaei A. A comparative study on the mechanical properties of the umbilical vein and umbilical artery under uniaxial loading. Artery Res 2014;8(2):51-6.
• [32] Husmann L, Leschka S, Desbiolles L, Schepis T, Gaemperli O, Seifert B, et al. Coronary artery motion and cardiac phases: dependency on heart rate-implications for CT image reconstruction. Radiology 2007;245(2):567-76.
• [33] Xie X, Wang Y, Zhou H. Impact of coronary tortuosity on the coronary blood flow: a 3D computational study. J Biomech 2013;46(11):1833-41.
• [34] Torii R, Keegan J, Wood NB, Dowsey AW, Hughes AD, Yang GZ, et al. The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study. Br J Radiol 2009;82(special_issue_1):S24-32.

Identyfikatory

DOI

10.1016/j.bbe.2024.05.002