Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

• Autorzy: Song, Yongcai , Su, Yujia , Tang, Cuiping
• Języki publikacji: EN

Abstrakty

EN

Rheumatoid arthritis is a chronic autoimmune-disease-causing inflammation, joint pain, and joint destruction, severely affecting the quality of life of millions worldwide. In the current research, a nanocarrier system was developed for the delivery of resveratrol and prednisolone to treat rheumatoid arthritis. The drug delivery system was characterized in vitro using scanning electron microscopy and various cell culture studies. Finally, the alleviative symptoms of the developed treatment strategy were investigated in a rat model of rheumatoid arthritis. In vitro studies showed that the carrier system released the drugs in a sustained manner and possessed strong immunomodulatory functions. Nanocarriers loaded with prednisolone, resveratrol, and drug-free carriers had 396.88 ± 76.41 nm, 392.49 ± 97.31 nm, and 338.02 ± 77.75 nm of mean particle size, respectively. In vivo studies revealed that local injection of the carrier system could alleviate the degenerative effects of rheumatoid arthritis. ELISA assays showed that the co-injection of resveratrol and prednisolone-loaded albumin nanoparticles could significantly modulate inflammatory responses. The developed treatment modality may potentially be used to treat rheumatoid arthritis.

Słowa kluczowe

EN

resveratrol; prednisolone; rheumatoid arthritis; albumin nanoparticles

• Czasopismo: Materials Science Poland
• Rocznik: 2024
• Tom: Vol. 42, No. 2
• Strony: 21--44
• Opis fizyczny: Bibliogr. 30, rys., tab.

Twórcy

autor

Song, Yongcai

• Department of Orthopaedic Trauma Joint, 3201 Hospital of Xi’an Jiaotong University Health Science CenterHanzhong, China

autor

Su, Yujia

• School of Medicine, Yunnan University, University Town East Outer Ring South RoadKunming, China Hussain Shaik Althaf Department of Zoology, College of Science, King Saud UniversityRiyadh, Saudi Arabia

autor

Tang, Cuiping

• Department of Rheumatology and Immunology, Xi’an Daxing HospitalXi’an, China,

Bibliografia

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Identyfikatory

DOI

10.2478/msp-2024-0005