Dichroizm kołowy kwasów nukleinowych. Cz.2. Polimery

• Autorzy: Boczkowska, M.

Warianty tytułu

EN

Circular dichroism of nucleic acids. Part 2. Polymers

• Języki publikacji: PL

Abstrakty

EN

The review presents the theoretical basis for interpretations of CD spectra of polynucleotides. A simplified version of quantum theory of circular dichroism of a polynucleotide by Tinoco and Johnson is presented in details. It is generally assumed that the optical activity of these polymers is dominated by interactions between dipoles of in-plane transitions occuring at neighbouring bases. The interaction of dipoles coming from different bases strictly depends on geometrical arrangement of bases within the helix. As a result information about geometry of the helix can be inferred from the CD spectra. The circular dichroism caused by the disturbance of the electronic system of a base by the presence of a sugar ring is usually omitted in calculations. Such a theoretical approach allows to understand differences between CD spectra of random DNA and RNA. The distance of a base pair from helix axis appeared to be the main factor responsible for these differences]. The approach fails in a case of polymers of non-random sequences, for example containing a repetitive motif of two bases. It is exemplified for the d(CG)n oligomers forming left-handed double helix called Z-DNA, where none of the theoretical calculations is able to predict the inversion of a CD spectrum characteristic for the Z form .

Słowa kluczowe

PL

dichroizm kołowy; kwas nukleinowy; polimery; aktywność optyczna

EN

circular dichroism; nucleic acids; polymers

• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2002
• Tom: [Z] 56, 3-4
• Strony: 203--221
• Opis fizyczny: Bibliogr. 41 poz., wykr.

Twórcy

autor

Boczkowska, M.

• Centrum Badań Molekularnych i Makromolekularnych PAN ul. Sienkiewicza 112, 90-363 Łódź

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