Synthesis and Transport Studies of Model Dipeptides with Modified N-terminal Amino Groups into E. coli K12 Mutant Strains

• Autorzy: Nowak-Jary, J. , Andruszkiewicz, R.
• Języki publikacji: EN

Abstrakty

EN

The synthesis of N-terminal guanidine derivatives of three dipeptides Ala-Ala, Ala-Leu, Ala-Phe and three dipeptides containing betaine as an N-terminal amino acid: Bet-Ala, Bet-Leu, Bet-Ile has been carried out. The transport studies of the obtained pseudo - peptides and corresponding natural peptides into E. coli K12 mutant strains have also been performed. The results indicate that modified dipeptides containing N-terminal guanidine or betaine are not transported into E. coli K12 cells.

Słowa kluczowe

EN

drug delivery; peptide transporters; guanidine derivatives; guanidylation reaction; betaines

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 11
• Strony: 1959--1966
• Opis fizyczny: Bibliogr. 16 poz., rys.

Twórcy

autor

Nowak-Jary, J.

autor

Andruszkiewicz, R.

• Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza, 80-233 Gdańsk, Poland,

Bibliografia

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