Search for New Synthetic Immunosuppressants. Antamanide Analogues Containing the Tetrazole Ring as a cis-Peptide Bond Mimetic

• Autorzy: Zubrzak, P. , Kaczmarek, K. , Kowalski, M. L. , Szkudlińska, B. , Zabrocki, J.
• Języki publikacji: EN

Abstrakty

EN

Linear and cyclic antamanide (ANT) analogues with dipeptide segments Pro2-Pro3, Pro7-Pro8 and both of them replaced by their tetrazole analogue Pro-psi[CN4]-Ala, respectively, have been synthesized by SPPS method and cyclization with TBTU reagent. The peptides were examined for their immunosuppressive activity in a lymphocyte proliferation test (LPT).

Słowa kluczowe

EN

antamanide; cis-peptide bond; 1,5-disubstituted tetrazole ring; immunosuppression

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 12
• Strony: 1869-1876
• Opis fizyczny: Bibliogr. 21 poz., rys.

Twórcy

autor

Zubrzak, P.

autor

Kaczmarek, K.

autor

Kowalski, M. L.

autor

Szkudlińska, B.

autor

Zabrocki, J.

• Institute of Organic Chemistry, Technical University, 90-924 Łódź, Żeromskiego 116, Poland