Synthesis of Isoquinoline Alkaloid, (š)-Salsolidine, Using Thiazolino[2,3-a]isoquinolinone S-Oxide as Intermediate

• Autorzy: Rozwadowska, M. D. , Sulima, A.
• Języki publikacji: EN

Abstrakty

EN

Thiazolino[2,3-a]isoquinolinones have been oxidized to the corresponding S-oxides and their 10b-methyl derivatives desulfurized with Raney nickel to give (š) N-acyl salsolidine. Base-catalyzed hydrolysis of the N-acetyl derivative afforded (š)-salsolidine. C-Methylation reactions of the title heterocyclic system have been investigated throughly. Stereochemistry ofthe synthesized compounds nas been established.

Słowa kluczowe

EN

thiazolino[2,3-a]isoquinolinone S-oxide; C-methylation; desulfurization; (š)-salsolidine; isoquinoline alkaloid

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 12
• Strony: 1847-1852
• Opis fizyczny: Bibliogr. 22 poz., rys.

Twórcy

autor

Rozwadowska, M. D.

autor

Sulima, A.

• Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland