Syntheses of Fmoc-alfa-aminoalkyltetrazoles and Tetrazole Analogue of Leu-enkephalin

• Autorzy: Manturewicz, M. , Kosson, P. , Grzonka, Z.
• Języki publikacji: EN

Abstrakty

EN

Five Fmoc-alfa-aminoalkyltetrazoleswere synthesized starting from Fmoc-alfa-amino acids. Fmoc-LeuT was applied in synthesis of tetrazole analogue of Leu-enkephalin by solid phase peptide synthesis (SPPS), aswell as in solution. Radioreceptor assays showed high affinity of [LeuT5]-enkephalin for opiate receptors.

Słowa kluczowe

EN

tetrazole analogues of F-moc-amino acids and peptides; [LeuT5]-enkephalin; solid phase peptide synthesis (SPPS)

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 7
• Strony: 1327-1334
• Opis fizyczny: Bibliogr. 22 poz., rys.

Twórcy

autor

Manturewicz, M.

autor

Kosson, P.

autor

Grzonka, Z.

• Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland,

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