Warianty tytułu
Języki publikacji
Abstrakty
A series of pyrimido[1,2-a]benzimidazole derivatives has been synthesized in the reactions of 2-aminobenzimidazole Schiff bases 1-6 with selected _-diketones; acetylacetone 7-12 or benzoylacetone 13-18. The structures 4, 7-18 were confirmed by the results of elemental analysis and their IR, 1H NMR and MS spectra. Compounds 4, 7-18 were examined for their antiproliferative activityin vitro against 3 cancer cell lines: P338 (mice leukemia), A549 (non-small cell lung carcinoma), SW707 (rectal adenocarcinoma), using SRB (sulphorhodamine B) or MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide) technique. The Schiff base 4 and tricyclic derivatives 9, 14, 16 exhibited the highest cytotoxic activity in vitro.
Czasopismo
Rocznik
Tom
Strony
279-287
Opis fizyczny
Bibliogr. 19 poz.
Twórcy
autor
autor
autor
autor
autor
autor
- Department of Technology of Drugs, Wroclaw University of Medicine, 50-140 Wroclaw, Nankier Sq. 1, Poland
Bibliografia
- 1. Nawrocka W., Sztuba B., Liszkiewicz H., Kowalska M.W., Wietrzyk J., Nevozhai D. and Opolski A., Polish J. Chem., 79, 709 (2005).
- 2. Singh A., Rai M. and Singal K.K., Indian J. Chem. Soc.,13, 991 (1975).
- 3. Rai M., Kumar S., Krishan K. and Singh A., Indian J. Chem., 17B, 987 (1979).
- 4. Rastogi R. and Sharma S., Synthesis, 861 (1983).
- 5. Nawrocka W., Boli. Chim. Farmaceutico, 135, 18 (1996).
- 6. Bassyouni F.A. and Ismail I.I., Afinidad LVIII, 495, 375 (2001).
- 7. Hoffmann B., Costisella B. and Seeboth H., Z. Chem., 28, 366 (1988).
- 8. Tatsushi N., Shinya K. and Tetsuzo K., Jpn. Kokai Tokkyo JP 61 63,680 [86 63,680] (1986); C.A. 105, 172498w(1986).
- 9. Nawrocka W., Sztuba B., Kowalska M.W., Wietrzyk J., Nasulewicz A., Pełczyńska M. and Opolski A., Farmaco, 54, 83 (2004).
- 10.Nawrocka W., Liszkiewicz H., Opolski A. and Wietrzyk J., Biul. Urz. Pat., 9 (818), 43, Al 362959 (2005).
- 11.Nawrocka W., Liszkiewicz H., Opolski A. and Wietrzyk J., Biul. Urz. Pat., 8 (817), 55, Al 362880 (2005).
- 12.Liszkiewicz H., Kowalska M.W., Głowiak T., Wietrzyk J. and Opolski A., Polish J. Chem., 76, 1607 (2002).
- 13.Silverstein R.M., Bassler G.C. and Morril T.C., Spectrometric Identification of Organie Compounds, 5th ed., John Wiley and Sons, Inc., New York 1991.
- 14.Hohenberg P. and Kohn W., Phys. Rev., 136, B864 (1964).
- 15.Kohn W. and Sham L.J., Phys. Rev., 140, A1133 (1965).
- 16.Becke A.D., J. Chem. Phys., 98, 5648 (1993).
- 17.Lee C., Yang W. and Parr R. G., Phys. Rev. B, 37, 785 (1988).
- 18.Gaussian 98 (Revision A.7), Frisch M.J., Trucks G.W., Schlegel H.B, Scuseria G.E., Robb M.A., Cheeseman J.R., Zakrzewski V.G., Montgomery J.A., Stratmann R.E., Burant J.C., Dapprich S., Millam J.M., Daniels A.D., Kudin K.N., Strain M.C., Farkas O., Tomasi J., Barone V., Cossi M., Cammi R., Mennucci B., Pomelli C., Adamo C., Clifford S., Ochterski J., Petersson G.A., Ayala P.Y., Cui Q., Morokuma K., Malick D.K., Rabuck A.D., Raghavachari K., Foresman J.B., Cioslowski J., Ortiz J.V., Stefanov B.B., Liu G., Liashenko A., Piskorz P., Komaromi L, Gomperts R., Martin R.L., Fox D.J., Keith T., Al-Laham M.A., Peng C.Y., Nanayakkara A., Gonzalez C., Challacombe M., Gili P.M. W., Johnson B.G., Chen W., Wong M.W., Andres J.L., Head-Gordon M., Replogle E.S. and Popie J.A., Gaussian, Inc., Pittsburgh PA, 1998.
- 19.Skeham P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J.T., Bokesh H., Kenney S. and Boyom M.R., J. Natl. Cancer. Inst., 82, 1107 (1990).
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ3-0006-0024