Lipoxygenase Inhibiting Steroidal Glycosides and Naphthene Derivatives from Haloxylon salicornicum

• Autorzy: Ferheen, S. , Ahmed, E. , Afza, N. , Malik, A. , Nawaz, S. , Choudhary, M.
• Języki publikacji: EN

Abstrakty

EN

Allostigmasterol glycosides 1 and 2 and monocyclic naphthene derivatives 3 and 4 have been isolated from methanolic extract of Haloxylon salicornicum and their structures elucidated through spectroscopy. Triacontanoic acid 5, ergosterol peroxide 6 and lupeol 7 were also obtained for the first time from this species. Both 1 and 2 showed moderate lipoxygenase inhibiting activity.

Słowa kluczowe

EN

Haloxylon salicornicum; Chenopodiaceae; steroidal glycosides; naphthenes; lipoxygenase inhibition

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2005
• Tom: Vol. 79 / nr 9
• Strony: 1469-1476
• Opis fizyczny: Bibliogr. 19 poz., rys.

Twórcy

autor

Ferheen, S.

• Pharmaceutical Research Centre, PCSIR Laboratories Karachi Complex,Karachi-75280, Pakistan

autor

Ahmed, E.

autor

Afza, N.

• Pharmaceutical Research Centre, PCSIR Laboratories Karachi Complex,Karachi-75280, Pakistan

autor

Malik, A.

• International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan,

autor

Nawaz, S.

• International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

autor

Choudhary, M.

• International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Bibliografia

• 1.Ali S.I. and Qaiser M., Flora of Pakistan., Vol 204, Department of Botany, University of Karachi Karachi, Pakistan, p. 185 (2001).
• 2.Chopra R.N., Nayar S.L. and Chopra I.C., Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research: New Delhi, India; p. 130 (1956).
• 3.Sastri B.N., The Wealth of India, Vol. 5, Council of Scientific and Industrial Research, New Delhi., p. 5 (1959).
• 4.Gibbons S., Denny B.J., Ali A.S., Mathew K.T., Skelton B.W., White A.H. and Gray A.I., J. Nat. Prod 63, 839 (2000).
• 5.Michel K.H. and Sandberg R, Acta Pharm. Suec., 4, 97 (1967).
• 6.Michel K.H., Sandberg R, Haglid R and Norin T., Acta Pharm. Suec., 4, 97 (1967).
• 7.Meyer B.N., Ferrigni N.R., Putnam J.E., Jacobsen L.B., Nicholas P.E. and McLaughlin J.L., Planta Medica, 45, 31 (1982).
• 8.Lands W.E.M., Adv. Drug Res., 14, 147 (1985).
• 9.Steinhilber D.A., Curr. Med. Chem., 6, 71 (1999).
• 10.Ding X.Y., Tong W.G. and Adrian. T.E., Pancreatology, 4, 291 (2001).
• 11.Russel E.M. and Thomas S.O., J. Am. Chem. Soc., 59, 2708 (1937).
• 12.Pfeffer P.E., Valentine K.M. and Parrish RW., J. Am. Chem. Soc., 102, 1264 (1979).
• 13.Gupta M.M. and Verma R.K., Phytochemistry, 30, 875 (1991).
• 14.Riendeau D. and Meighen E., Experientia, 41, 707 (1985).
• 15.Cocker W., and Shaw S.J., J. Chem. Soc., 5194 (1962).
• 16.Burns D., Reynold W.R, Buchanan G., Reese P.B. and Enriquez R.G., Magn. Res. Chem., 38, 488 (2000).
• 17.Monaco P. and Previtera L., J. Nat. Prod., 41, 673 (1984).
• 18.Gunatilaka, L.A.A., Gopichand T., Schmitz F.J. and Djerassi C., J. Org. Chem., 46, 3860 (1981).
• 19.Tappel A.L., Methods in Enzymology, Vol. 5: Academic Press New York, p. 539 (1962).