Structure and activity studies of glycine receptor ligands : Part 4. N-[(7-arylalkyl, 7-aryloxyalkyl)-8-theophyllyl]-glycines

• Autorzy: Drabczyńska, A. , Karolak-Wojciechowska, J. , Kieć-Kononowicz, K.
• Języki publikacji: EN

Abstrakty

EN

Preparation of N-[(7-arylalkyl, 7-aryloxyalkyl)-8-theophyllyl]-glycines by condensation of 8-bromo-theophylline with arylalkyl- and aryloxyalkylbromides and aminolysis with glycine is described. The structure of one of the obtained glycine derivatives was confirmed by X-ray analysis. A comparison of the glycine receptor binding model (molecule L-689,560) and the 3-D structure of that molecule indicates serious differences in molecule shape, explaining their inactivity.

Słowa kluczowe

EN

glycine receptor ligands

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1999
• Tom: vol. 73 nr 5
• Strony: 783-792

Twórcy

autor

Drabczyńska, A.

autor

Karolak-Wojciechowska, J.

autor

Kieć-Kononowicz, K.

• Collegium Medicum Uniwersytet Jagielloński ul. Medyczna 9 30-688 Kraków