Urease Inhibiting Guaianolides from Amberboa ramosa

• Autorzy: Khan, S. , Riaz, N. , Afza, N. , Malik, A. , Azhar-ul-Haq , Ahmed, Z. , Lodhi, M. , Choudhary, M.
• Języki publikacji: EN

Abstrakty

EN

New sesquiterpene lactones have been isolated from the chloroform-soluble fraction of Amberboa ramosa and assigned two structures 4 beta-(chloromethyl)-3 beta, 4 alfa-dihydroxy, 8alfa-[(s)-2-carboxypropionoxy]-1alfaH,5alfaH,6betaH,7alfaH-guaia-10(14),11(13)-dien- 6,12-olide (1) and 4 beta(chloromethyl)-3beta ,4alfa-dihydroxy,8alfa-[(s)-3-hydroxy-2-methylpropionyloxy]- 1alfaH,5alfaH,6beta H,7alfaH-guaia-10(14),11(13)-dien-6,12-olide (2), respectively. In addition 5-hydroxy-6-methyl-7-methoxyflavone (3), 6,2',5'-trihydroxy-3,5,7-trimethoxyflavone (4) and 5-hydroxy-3,7,8,2'-tetramethoxyflavone (5) have also been reported for the first time from this species. Compounds 1 and 2 displayed promising inhibitory potential against enzyme urease in a concentration-dependent fashion.

Słowa kluczowe

EN

Amberboa ramosa; compositae; guaianolide; urease inhibition

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2004
• Tom: Vol.78 /nr 11-12
• Strony: 2075-2080
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Khan, S.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Riaz, N.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Afza, N.

autor

Malik, A.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Azhar-ul-Haq

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Ahmed, Z.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Lodhi, M.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

autor

Choudhary, M.

• International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi; Karachi-75270, Pakistan

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