Bionic design of tube formation in the integrated cellular structure

• Autorzy: Tanishita, K. , Ueda, A. , Sudo, R. , Ikeda, M. , Mitaka, T.
• Języki publikacji: EN

Abstrakty

EN

The individual cells in the reconstructed cellular structures do not necessarily receive sufficient oxygen and necessary substances supply only by diffusion, and it is necessary to install a blood vessel network formation in the cellular structure. In other words, the vessel network formation is essentially required to achieve cellular function, and to develop a technology of reconstruction of the vessel network installed in the three-dimensional cellular architecture is needed. Here the procedure of the tube formation of blood vessels and bile canaliculi (BC) in vitro is focused on, demonstrating a possibility of tube formation in cellular structures reconstructed in vitro. Particularly, attention to the role of biomechanical processes in the tube formation was paid.

Słowa kluczowe

PL

tworzenie sieci; kanaliki żółciowe; komórka wątrobowa; komórka śródnabłonka

EN

network formation; small hepatocytes; bile canaliculi; endothelial cell

• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2007
• Tom: Vol. 27, no. 1-2
• Strony: 83-87
• Opis fizyczny: Bibliogr. 5 poz., rys., wykr.

Twórcy

autor

Tanishita, K.

autor

Ueda, A.

autor

Sudo, R.

autor

Ikeda, M.

autor

Mitaka, T.

• Departament of System Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan,

Bibliografia

• 1. Harimoto M., Yamato M., Hirose M., Takahashi C., Isoi Y, Kikuchi A., Okano T.: Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto mono-layer hepatocytes utilizing temperature-responsive culture dishes, J. Biomed. Mater. Re., 2002, 62, 464-470.
• 2. Ueda A., Koga M., Ikeda M., Kudo S., Tanishita K.: Effect of shear stress on micro-vessels network formation of endothelial cells with in vitro three-dimensional model, American J. Physiology Heart Circ. Physiol. 2004, 287, H994-H1002.
• 3. Sudo R., Mitaka T., Ikeda S., Sugimoto S., Harada K., Hirata K., Tanishita K., Mochizuki Y: Bile canalicular formation in hepatic organoid reconstructed by rat small hepatocytes and hepatic nonparenchymal cells, J. Cellular Physiol. 2004,199, 252-261.
• 4. Sudo R., Kohara H., Mitaka T., Ikeda M., Tanishita K.: Coordinated movement of bile canalicular networks reconstructed by rat small hepatocytes, Annals of Biomed. Eng. 2005, 33(5), 696-708.
• 5. Sudo R., Mitaka T., Ikeda M., Tanishta K.: Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membrance, The FASEB Journal, published on line August 17, 2005.