The influence of transplantation of encapsulated porcine islets on glycemia in diabetic mice

• Autorzy: Kinasiewicz, J. , Sabat, M. , Godlewska, E. , Orłowski, T.
• Języki publikacji: EN

Abstrakty

EN

Transplantation of pancreatic islets is a promising therapy of type I diabetes. Human donor shortage may be alleviated by transplantation of porcine islets. Unfortunately to prevent graft rejection immunosuppresion or immunoisolation is mandatory. In this paper we demostrate, that xenotransplantation of porcine islets microencapsulated in algiate/poly-L-lysine/alginate microcapsules to streptozotocin diabetic mice can reverse hypoglykemia but unfortunatelly the fenomenon of primary graft nonfunction (PNF) can frequently be noted.

Słowa kluczowe

EN

pig islet xenotransplantation; primary graft nonfunction; islet encapsulation

• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2004
• Tom: Vol. 24, no. 4
• Strony: 67-70
• Opis fizyczny: Bibliogr. 12 poz.

Twórcy

autor

Kinasiewicz, J.

• Polish Academy of Sciences, Institute of Biocybernetics and Biomedical Engineering, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland,

autor

Sabat, M.

• Transplantation Institute, Warsaw Medical University, Warsaw, Poland

autor

Godlewska, E.

• Polish Academy of Sciences, Institute of Biocybernetics and Biomedical Engineering, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland

autor

Orłowski, T.

• Polish Academy of Sciences, Institute of Biocybernetics and Biomedical Engineering, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland

Bibliografia

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