Assessment of the lactide-co-glycolide and its composite degradation velocity under in vitro and in vivo conditions

• Autorzy: Chłopek, J. , Morawska-Chochół, A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this work was the analysis of the modifying phase effect (hydroxyapatite particles and carbon fibres) and environment role (in vitro and in vivo) on mechanism and velocity of the resorption process of polylactide-co-glycolide (PGLA). Resorption time of samples incubated in simulated biological environment was determined on the basis of pH changes of the Ringer's solution. Scanning electron microscopy and infrared spectroscopy were applied for the estimation of the resorption degree of the polymer. It was observed that carbon fibres addition accelerates distinctly in vitro matrix degradation, whereas in the natural biological environment fibres reduce this time. In the case of composite with hydroxyapatite nanoparticles the in vitro processes are complex and difficult to explain. In this case simultaneous occurrence of three processes is possible: polymer resorption, HAP precipitation and dissolution. In the biological environment reduce polymer resorption time is no-ticeable.

Słowa kluczowe

EN

resorbable polymer; carbon fibres; hydroxyapatite; in vivo; in vitro

• Czasopismo: Advances in Materials Science
• Rocznik: 2007
• Tom: Vol. 7, nr 2(12)
• Strony: 86-91
• Opis fizyczny: Bibliogr. 8 poz., rys.

Twórcy

autor

Chłopek, J.

autor

Morawska-Chochół, A.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, Cra-cow, Poland

Bibliografia

• [1] Blażewicz M.: Carbon materials in the treatment of soft and bard tissue injuries. European Cells and Materials 2 (2001), pp. 21-29
• [2] Błażewicz M., Paluszkiewicz Cz.: Characterization of biomaterials used for bane regeneration by FTIR spectroscopy. Journal of Molecular Structure 563-564 (2001), pp. 147-152.
• [3] Ignjatovic N., Uskokovic D.: Synthesis and applications of hydroxyapatite / polylactide composite biomaterials. Applied Surface Science 238 (2004), pp.314-319.
• [4] Dobrzyński P., Kasperczyk J., Bero M.: Nowe możliwości syntezy i zastosowania w medycynie biodegradowalnych kopolimerów glikolidu nie zawierających cyny. Eng. Biomat. 23-25 (2002), pp. 27-29.
• [5] Haberko K. Bućko M., Haberko M., Mozga W., Pyda A., Zarębski J.: Hydroksyapatyt naturalny – preparatyka, właściwości Eng. Biomat. 30-33 (2003), pp. 32-38.
• [6] Pamuła E., Dobrzyński P., Bero M., Paluszkiewicz C.: Hydrolytic degradation of porous scaffolds for tissue engineering from terpolymer of L-lactide, 3-caprolactone and glycolide. Journal of Molecular Structure 744-747 (2005) 557-562.
• [7] Gadotta D.: A Literature Review of Poly(Lactic Acid). Journal of Polymers and the Environment 9, 2 (2001), pp. 63-84.
• [8] Błażewicz M., Chomyszyn-Gajewska M., Paluszkiewicz Cz.: Application of vibrational spectroscopy in the in vitro studies of carbon fiber-polylactic acid composite degradation. Journal of Molecular Structure 482-483 (1999), pp. 519-524.