Impact of the charge density of phospholipid bilayers on lubrication of articular cartilage surfaces

• Autorzy: Pawlak, Z. , Kotynska, J. , Figaszewski, Z. A. , Oloyede, A. , Gadomski, A. , Gudaniec, A.
• Języki publikacji: EN

Abstrakty

EN

Purpose: We attempt to answer the question how some changes in acid - base equilibrium have an impact on the charge density of a phospholipid bilayer formed during lubrication occurring at articular cartilage surfaces. Design/methodology/approach: Liposomes have been used to mimic biological phospholipid membranes on articular cartilage surface where proteins are bounded, ions are transported, energy is transducted, and cellular processes are taking place. The charge density of the membrane was determined as a function of pH and electrolyte concentration from the microelectrophoretic method. Liposome membrane has been prepared as an aqueous solution of NaCl under various pH conditions. Microelectrophoresis was used to examine the local acid-base equilibrium of the electrolytes with the membrane surface, which can be considered to be an interface of phospholipids in articular cartilage. Findings: The effects of the adsorption of ions (H+, OH- ; Na+, CI-), which are present in solution upon electric charge of the liposome membrane assembled of phosphatidycholine (PC), have also been found to exhibit pH-responsive (quasi-periodic) behavior. Research limitations/implications: We hypothesized that the acid-base dissociation behavior in phospholipid bilayers of articular cartilage is a key to understanding biolubrication processes. For example, similar previous investigators found that the behavior of a multilayer made of polyisopeptide/hyaluronic acid depends on some of the surface properties such as film thickness, surface friction, surface wetness and swelling conditions. Future work should consider the adsorption of polyelectrolyte ions, e.g., the glycoprotein lubricin and hyaluronan, at the liposome membrane surface involved, assumed that besides the H+ and OH- ions, the polyelectolyte ions were also engaged. Originality/value: This liposome membrane is a model for phospholipid bilayers and will be applied for the investigation of polyelectrolyte ions, e.g. lubricin, in articular cartilage conditions. We demonstrate that knowledge on the acid-base processes on charged surface is the key to understanding phenomena occurring at interfaces in human joints lubrication, thus pointing to the biolubrication as a charged interface-controlled process.

Słowa kluczowe

PL

właściwości elektryczne; biomateriały; smarowanie; chrząstka stawowa

EN

electrical properties; biomaterials; lubrication; articular cartilage

• Czasopismo: Journal of Achievements in Materials and Manufacturing Engineering
• Rocznik: 2007
• Tom: Vol. 23, nr 1
• Strony: 47-50
• Opis fizyczny: Bibliogr. 33 poz., rys.

Twórcy

autor

Pawlak, Z.

autor

Kotynska, J.

autor

Figaszewski, Z. A.

autor

Oloyede, A.

autor

Gadomski, A.

autor

Gudaniec, A.

• Queensland University of Technology, School of Engineering Systems, GPO Box 2434 Brisbane, Q 4001, Australia,

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