Purine nucleoside analogues. 8. N(2) - acetylation of guanine derivatives

• Autorzy: Madre, M. , Zhuk, R. , Golankiewicz, B.
• Języki publikacji: EN

Abstrakty

EN

A method for the acetylation of the exocyclic amino group of guanine derivatives has been developed. A series of N(2)-acetylguanines was synthesized by reacting of N-9(7)-alkoxyalkylguanines with an excess of acetic anhydride in the presence of 4-dimethylaminopyridine. The method has been used successfully also for N(2)-acetylation of guanosine and its 8-bromo derivative although in the latter case a partial substitution of bromine for a hydroxy group at the position 8 of the heterocycle occurred.

Słowa kluczowe

EN

N9(7)-alkoxyalkylguanines; guanosine; N(2)-acetylation

• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1998
• Tom: Vol. 72, nr 10
• Strony: 2242-2246
• Opis fizyczny: Bibliogr. 10 poz.

Twórcy

autor

Madre, M.

autor

Zhuk, R.

autor

Golankiewicz, B.

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, ul. Noskowskiego 12/14 61-704 Poznań, Poland