The outer-membrane component of the multi-drug efflux system - a structural analysis based on hydrophobicity distribution

• Autorzy: Roterman, Irena , Konieczny, Leszek , Stapor, Katarzyna
• Języki publikacji: EN

Abstrakty

EN

Aim: The structure of a multi-drug efflux system (specifically the outer membrane part) is the focus of our analysis. The role of electrostatic interactions in the efflux process is well understood. Methods: Our analysis is made possible by the application of the fuzzy oil drop model in its modified form (FOD-M). Results: The distribution of hydrophobicity in the periplasmic and membrane domains plays a significant role in both stabilisation within the membrane and in tunnel formation, which facilitates the transport of antibiotics. Conclusions: The analysis presented in this paper reveals the specificity of hydrophobicity distribution in relation to biological activity, as well as a possible mechanism for the folding process of proteins involved in multi-drug efflux.

Słowa kluczowe

EN

membrane proteins; hydrophobicity; efflux; outer membrane proteins; efflux pumps

• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2024
• Tom: Vol. 20, no. 1
• Strony: 1--14
• Opis fizyczny: Bibliogr. 33 poz., rys., tab.

Twórcy

autor

Roterman, Irena

• Department of Bioinformatics and Telemedicine, Jagiellonian University - Medical College, Krakow, Poland,

autor

Konieczny, Leszek

• Chair of Medical Biochemistry, Jagiellonian University - Medical College, Krakow, Poland

autor

Stapor, Katarzyna

• Faculty of Automatic, Electronics and Computer Science, Department of Applied Informatics, Silesian University of Technology, Gliwice, Poland

Bibliografia

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Identyfikatory

DOI

10.5604/01.3001.0054.7083