Fungicidal activity of alkaloid from Colchicum species and its complexes

• Autorzy: Kwaśniewska-Sip, P. , Cofta, G. , Kurek, J.
• Języki publikacji: EN

Abstrakty

EN

The colchicine complexes with Na+ , K+ Mg2+ and Ca2+ cations of sulphates and carbonates have been synthesized and were tested against fungicidal activity. The obtained complexes were tested to determined minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) against microfungi using 96-well microtiter plate-based method. The colchicine itself wasn’t active against most of used microfungi with the exception of A. pullulans. Colchicine complexes with K2CO3 and MgSO4 inhibited growth the majority of tested microfungi.

Słowa kluczowe

EN

colchicine; colchicine complexes; omplexesfungicidal activity

• Czasopismo: Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology
• Rocznik: 2018
• Tom: No. 104
• Strony: 252--255
• Opis fizyczny: Bibliogr. 6 poz.

Twórcy

autor

Kwaśniewska-Sip, P.

• Wood Technology Institute, Environmental Protection and Wood Chemistry Department, Winiarska 1, 60-654 Poznan, Poland

autor

Cofta, G.

• Institute of Chemical Wood Technology, University of Life Science, Wojska Polskiego 38/42, 60-037 Poznań, Poland

autor

Kurek, J.

• Faculty of Chemistry, A. Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland

Bibliografia

• 1. KLINTSCHER M. BEHAM-SCHMIDT C, RADNER H, HENNING G, ROLL P. 1999: Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects, Forensic Sci. Int. 106, 191.
• 2. SCHONHARTING M., MENDE G., SIEBERT G., HOPPE – Seyler’s Zeitschrift für physiologische Chemie. 355, 1991, 1974.
• 3. CAVAZZA M, PIETRA F. 2003: Fluxional sulfonyl derivatives of troponoids and colchicinoids, Tetrahedron Letters, 1895; 44-48.
• 4. KUREK J. BOCZOŃW., RZYBYLSKIP. BRZEZINSK B. 2007: ESI MS, spectroscopic and PM5 semiempirical studies of Colchicine complexes with lithium, sodium and potassium salts J. Mol. Struct. 846,13.
• 5. KUREK J., BARCZYŃSKI P. 2016: Colchiceine complexes with lithium, sodium and potassium salts - spectroscopic studies. Croatica Chemica Acta 89, (3) 1-12.
• 6. KUREK J.. BARTKOWIAK G., JANKOWSKI W., KWAŚNIEWSKA-SIP P., SCHROEDER G., HOFFMANN M., COFTA G., BARCZYŃSKI P. 2016: Human body fluid ions in colchicine complexes ESI MS, MADLI MS, Spectroscopic, DFT studies and fungicidal activity of colchicine complexes with sodium, potassium, magnesium and calcium carbonates and Sulphates. IOSR Journal Of Pharmacy 6, (8) 40.

Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).