Synthesis, characterization and biological evaluation of 2,5-di-substituted 1,3,4-oxadiazole derivatives

• Autorzy: Makwana, H. , Naliapara, Y. T.
• Języki publikacji: EN

Abstrakty

EN

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

Słowa kluczowe

EN

substituted 1,2,3,4-oxadiazoles; phosphoric anhydride; antimicrobial activity

• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 15
• Strony: 48--54
• Opis fizyczny: Bibliogr. 15 poz., tab., wz.

Twórcy

autor

Makwana, H.

• Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India

autor

Naliapara, Y. T.

• Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India,

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