Synthesis, Characterization and Anti-diabetic activity of 1,3,5-triaryl-2-pyrazolines in acetic acid solution under Ultrasound Irradiation

• Autorzy: Emayavaramban, M. , Santhi, N. , Gopi, C. , Manivannan, C. , Raguraman, A.
• Języki publikacji: EN

Abstrakty

EN

A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide / semicarbazide hydrochloride / benzhydrazide / benzenesulphonyl hydrazide / phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13CNMR spectral data. All the target compounds were evaluated for their in-vivo anti - diabetic activity in rates in comparison with as reference drug.

Słowa kluczowe

EN

Chalcone; Pyrazoline; ultrasound irradiation; Anti-diabtic activity and Alloxan Monohydrate

• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2013
• Tom: Vol. 9, iss. 2
• Strony: 172-185
• Opis fizyczny: Bibliogr. 28 poz., tab., wz.

Twórcy

autor

Emayavaramban, M.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Santhi, N.

• Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India,

autor

Gopi, C.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Manivannan, C.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Raguraman, A.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

Bibliografia

• [1] Maiti R., Jana D., Das U. K., Ghosh D., J. Ethnopharmacol 92 (2004) 85-91.
• [2] World Health Organization; Fact sheet No-312, November 2009. http://www.who.int/mediacentre/factsheets/fs312/en/index.html
• [3] Susheela T., Padma Balaravi, Jane Theophilus, Narender Reddy, Reddy P. U. M., Curr. Sci. 94(9) (2008) 1191.
• [4] Diabetes Statistics: India Is the Diabetic Capital of The World, http://health.savvy-cafe.com/diabetes-statistics-india-is-the-diabetic-capital-of-the-world.
• [5] Bhupesh C. M., Kamal S., Nagendra S. C., Rohit B., Kalyani D., Int. J. Pharm. 6 (2008) 1-6.
• [6] Gerritsen G. C., Dulin W. E., Kalamazoo P. D., Diabetes 14 (1965) 102. Smith D. L., Forist A. A., Dulin W. E., J. Med. Chem. 1965, 350.
• [7] ElShora AI., Egypt J. Sol. 23 (2000) 251-254
• [8] Sobhia H. R., Yaminib Y., Esrafili A., Adiba M., J. Pharm, Biomed. Anal. 45 (2008) 316-320. [9] Nauduri D., Reddy G. B., Pharm. Bull. Tokyo 46 (1998) 1254.
• [10] Korgaokar S. S., Patil P. H., Shah M. T., Parekh H. H., Indian J. Pharm. Sci. 58 (1996) 222.
• [11] Udupi R. H., Kushnoor A. R., Bhat A. R., Indian J. Heterocyclic Chem. 8 (1998) 63.
• [12] Delay F. (S. A. Fermeinch), Patentschriff (Switz) C. A. 117 (1992) 90276f.
• [13] Geigy J. R., Belg, 466668, Aug. 31, 1942; C.A., 39 (1945) 7848.
• [14] Reddy D. B., Senshama T., Ramma Reddy B. M. V., Indian J. Chem. 30(B) (1991) 46.
• [15] Zalgislaw K.. Zbigniew, Acta. Pol Pharm 36(6) (1979) 645: C.A., 93 (1980) 204525e.
• [16] Yamashita Hiroyuti, Odata Mocoto, Kawazara Hirahi, Namekawa Hiroshi, Eur. Patent appl. Ep1988; 295695CL.Co7D401/6) J. P. Appl.87(1987)148919, C.A, 111(1989)2351
• [17] Bauer A. N., Kirby W. N. M., Sherries J. C., Truck M., Am. J. Clin. Pathol. 45 (1996) 493 (1996).
• [18] Yanarday R., Colak H., Pharm Pharmacol Comno 4 (1998) 309.
• [19] Ragini Gupta, Neetu Gupta, Anshu Jain, Indian Journal of Chemistry 49B (2010) 351-355
• [20] Naglaa M. A. E., Tamer S. S., Mohamed F. M., Ultrason. Sonochem. 16 (2009) 70.
• [21] C. Guofeng, L. Jitai, D. Huiyun, L. Tongshuang, C. J. I. 6 (1), 6 (2004).
• [22] D. Azarifar, M. Shaebanzadeh, Molecules 7 (2002) 885.
• [23] Prince S. M., Menon V. P., J. Ethnopharmacol. 70 (2000) 9-15.
• [24] Jelodar G., Mohsen M., Shahram S., African J. Traditional, Complementary and Alternative Medicines 3 (2003) 299-305.
• [25] Grover J. K., Vats V., Rathi S. S., J. Ethnopharmacol. 73 (2000) 461-470.
• [26] Shanmugasundaram K. R., Panneerselvam S. P., Shanmugasundaram E. R. B., R. Br. J. Ethnopharmacol. 7 (1983) 205-216..
• [27] Begum N., Shanmugasudnaram K. R., J. Health Sci. 4 (1978) 129-139.
• [28] Mohamed A. K., Bierhaus A., Sciekofer S., Tritschler H., Ziegler H., Nawroth P. P., Biofactors 10 (1999) 175.