Determination of the Dexlansoprazole in Bulk and Spiked Human Plasma by Extraction Spectrophotometry

• Autorzy: Sekharan, C. B. , Rao, M. P. , Mahesh, M. , Chandramouli, I. , Seemanth, J.
• Języki publikacji: EN

Abstrakty

EN

This paper describes a simple extraction spectrophotometric method for the quantification of dexlansoprazole in bulk and spiked human plasma. This method involves formation of stable yellow colored chloroform extractable ion-pair complex of the amino derivative of dexlansoprazole with acid dye, namely methyl orange in acidic medium. The ion-pair complexes exhibit absorption maxima at 425 nm. Dexlansoprazole can be determined up to 4-40 μg/mL by the proposed method. The effect of optimum reagent concentration was studied. The relative standard deviations (≤1. 246%) obtained in the intra-day and inter-day analyses were found to be satisfactory. The accuracy results exhibited the mean recovery and percentage error in the range of 99.137%–100.574% and 0.012%–0.863%. When applied for the assay of the dexlansoprazole in spiked human plasma sample, recovery mean values ranged from 96.495–98.960%. The proposed method is useful for the estimation of the dexlansoprazole in bulk and human plasma samples.

Słowa kluczowe

EN

Dexlansoprazole; methyl orange; spectrophotometry; Spiked Plasma Sample

• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2015
• Tom: Vol. 52
• Strony: 28--38
• Opis fizyczny: Bibliogr. 17 poz., rys., wz.

Twórcy

autor

Sekharan, C. B.

• Department of Pharmaceutical Biotechnology and Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601.,

autor

Rao, M. P.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Mahesh, M.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Chandramouli, I.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Seemanth, J.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

Bibliografia

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Identyfikatory

DOI

10.18052/www.scipress.com/ILCPA.52.28