Analysis of related substances in bisoprolol fumarate on sub-2-μm adsorbents

• Autorzy: Szalka, M. , Kostka, J. , Rokaszewski, E. , Kaczmarski, K.
• Języki publikacji: EN

Abstrakty

EN

The new analytical method of very high pressure liquid chromatography (VHPLC) has been designed for the estimation of related substances in bisoprolol fumarate. Several columns filled with sub-2-μm totally porous and shell adsorbent have been tested and compared during the method development. The columns’ resolution was investigated. The shell adsorbent appears to have smaller resolution than the totally porous adsorbent. The tips and recommendations for the HPLC-VHPLC method transfer are presented. Significant reduction in analysis run time and solvent consumption has been obtained.

Słowa kluczowe

EN

VHPLC; HPLC; bisoprolol fumarate; resolution factor; shell adsorbent

• Czasopismo: Acta Chromatographica
• Rocznik: 2012
• Tom: Vol. 24, no. 2
• Strony: 163--183
• Opis fizyczny: Bibliogr. 21 poz., rys., tab.

Twórcy

autor

Szalka, M.

• ICN Polfa Rzeszów S.A. Product Development Department 35-959 Rzeszów Poland

autor

Kostka, J.

• Rzeszów University of Technology Department of Chemical and Process Engineering 35-959 Rzeszów

autor

Rokaszewski, E.

• ICN Polfa Rzeszów S.A. Product Development Department 35-959 Rzeszów Poland

autor

Kaczmarski, K.

• Rzeszów University of Technology Department of Chemical and Process Engineering 35-959 Rzeszów,

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