Czasopismo
Tytuł artykułu
Treść / Zawartość
Pełne teksty:
Warianty tytułu
Języki publikacji
Abstrakty
The aim of this study was to verify the glycaemia-lowering activity of L-arabinose. The experiment was conducted on 3 individual days, each separated by a week. At the beginning of each week rats were subjected to an oral glucose, sucrose or starch tolerance test. Five minutes prior to each test rats were gavaged with water (a control), an aqueous solution of acarbose (a positive control) and L-arabinose. There was no effect of L-arabinose on glycaemia in the glucose tolerance test, whereas it reduced postprandial glycaemia after 15 min of the sucrose tolerance test. In the starch tolerance test, the glycaemia after L-arabinose ingestion was signifi cantly decreased both at time intervals and in total. Inhibition of enzyme activity involved in starch digestion (amylase, maltase) may be suggested as the most probable mechanism responsible for the observed effects.
Słowa kluczowe
Wydawca
Rocznik
Tom
Numer
Opis fizyczny
p.57-60,fig.,ref.
Twórcy
autor
- Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10–748 Olsztyn, Poland
autor
- MarMar Investment sp. z o.o., 8/3A Rydygiera Street, 00–793 Warsaw, Poland
autor
- Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10–748 Olsztyn, Poland
autor
- MarMar Investment sp. z o.o., 8/3A Rydygiera Street, 00–793 Warsaw, Poland
Bibliografia
- 1. Center for Drug Evaluation and Research. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. U.S. Food and Drug Administration 2005, Rockville, Maryland, USA.
- 2. Collene A.L., Hertzler S.R., Williams J.A., Wolf B.W, Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. Nutrition, 2005, 21, 848-854.
- 3. Kaats G.R., Keith S.C., Keith P.L., Leckie R.B., Perricone N.V, Preuss H.G., A combination of L-arabinose and chromium lowers circulating glucose and insulin levels after an acute oral sucrose challenge. Nutr. J., 2011, 10, Article no. 42.
- 4. Krog-Mikkelsen I., Hels O., Tetens I., Holst J.J., Andersen J.R., Bukhave K., The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans. Am. J. Clin. Nutr., 2011, 94, 472-478.
- 5. Kumar R.V, Sinha VR., Newer insights into the drug delivery approaches of a-glucosidase inhibitors. Expert Opin. Drug Deliv., 2012, 9, 403-416.
- 6. Li Y.S., Li X.H., Tan C.X., An improved method for the isolation of l-arabinose and d-galactose from gum arabic. Org. Prep. Proced. Int., 2013, 45, 332-335.
- 7. Loi B., Fantini N., Colombo G., Gessa G.L., Riva A., Bombardelli E., Morazzoni P., Carai M.A.M., Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats. Phytother. Res., 2013, 27, 258-263.
- 8. Osaki S., Kimura T., Sugimoto T., Hizukuri S., Iritani N., L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. J. Nutr., 2001, 131, 796-799.
- 9. Preuss H.G., Echard B., Bagchi D., Stohs S., Inhibition by natural dietary substances of gastrointestinal absorption of starch and sucrose in rats and pigs: 1. Acute studies. Int. J. Med. Sci., 2007, 4, 196-202.
- 10. Reagan-Shaw S., Nihal M., Ahmad N., Dose translation from animal to human studies revisited. FASEB J., 2008, 22, 659-661.
- 11. Said O., Fulder S., Khalil K., Azaizeh H., Kassis E., Saad B., Maintaining a physiological blood glucose level with glucolevel, a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid. Based Complement. Alternat. Med., 2008, 5, 421-428.
- 12. Seri K., Sanai K., Matsuo N., Kawakubo K., Xue C., Inoue S., L-arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. Metabolism, 1996, 45, 1368-1374.
- 13. Shibanuma K., Degawa Y., Houda K., Determination of the transient period of the EIS complex and investigation of the suppression of blood glucose levels by L-arabinose in healthy adults. Eur. J. Nutr., 2011, 50, 447-453.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-f23e0af3-09df-4b21-ac2c-b098a0b52c0a