The vasopressin deficient Brattleboro rat as a good animal model of schizophrenia

• Autorzy: Zelena D. , Varga J. , Fodor A. , Klausz B.
• Języki publikacji: EN

Abstrakty

EN

Schizophrenia is a devastating disorder for the afflicted people and very costly for the society. Therapy is not solved and preclinical testing requires animal models. Several studies suggested that vasopressin is important in schizophrenia. Patients have lower plasma vasopressin levels, which was normalized after antipsychotic treatment. Prepulse inhibition (PPI) is reduced in unmedicated schizophrenic patients, which correlates with the degree of thought disorder. Therefore the vasopressin-deficient Brattleboro rat might be an appropriate model. Indeed, they have a number of cognitive and behavioral abnormalities that are analogous to those seen in schizophrenia patients. Beside the reduced PPI, their object, as well as social discrimination abilities are also poor. In connection with social communication deficit pups emit less ultrasound upon maternal separation. EEG analysis showed circadian rhythm alterations in vasopressin-deficient rats; they spent more time awake during their inactive phase. After antipsychotic treatment all of these changes was normalized. Although these alterations might be observable in other mental disorders, but all data together and the response to antipsychotic treatment suggest that Brattleboro rats are unique model of schizophrenia having a natural (nonpharmacological) deficit in all above mentioned tests.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.353

Twórcy

autor

Zelena D.

• Laboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary

autor

Varga J.

• Laboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary

autor

Fodor A.

• Laboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary

autor

Klausz B.

• Laboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary