Influence of gamma-butyrolactone derivatives with analgesic properties on the prostaglandin E2 level and gastric mucosa in rodents

• Autorzy: Salat K. , Librowski T. , Gdula-Argasinska J. , Tyszka-Czochara M. , Jastrzebska-Wiesek M. , Moniczewski A. , Rapacz A. , Pytka K. , Filipek B. , Wieckowski K. , Malawska B.
• Języki publikacji: EN

Abstrakty

EN

Our recent studies indicate that some derivatives of gamma-butyrolactone (GBL) possess analgesic properties in rodent models of pain and inflammation. Despite this pronounced biological activity, the mechanism of action of these GBL still remains unclear. Searching for the plausible mechanism of their action we investigated whether they were (similarly to nonsteroidal anti-inflammatoiy drugs) capable of influencing the PGE2 level in mice subjected experimentally to zymosan-induced peritonitis. The PGE2 level was evaluated in vitro by means of the ELISA assay. We also investigated the influence of orally administered GBL on the rat gastric mucosa in post mortem studies. We have demonstrated that neither of the GBL derivatives influences the PGE2 level in zymosan-induced inflammation of the peritoneal cavity in mice. The investigated compounds are also devoid of adverse effects within the stomach, typical of cyclooxygenase inhibitors, which also indirectly suggests that their analgesic and anti-inflammatory activities result from mechanisms other than cyclooxygenase inhibition.

• Wydawca: -
• Czasopismo: Acta Biologica Cracoviensia. Series Zoologia
• Rocznik: 2012
• Tom: 54
• Opis fizyczny: p.45-52,fig.,ref.

Twórcy

autor

Salat K.

• Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Librowski T.

• Department of Radioligands, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Gdula-Argasinska J.

• Department of Radioligands, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Tyszka-Czochara M.

• Department of Radioligands, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Jastrzebska-Wiesek M.

• Department of Clinical Pharmacy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Moniczewski A.

• Department of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Rapacz A.

• Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Pytka K.

• Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Filipek B.

• Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Wieckowski K.

• Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

autor

Malawska B.

• Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Street, 30-688 Krakow, Poland

Uwagi

PL

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