State related changes of information flow in thalamo-cortical path ways

• Autorzy: Kubik E.
• Języki publikacji: EN

Abstrakty

EN

Depending on the level of arousal identical sensory stimuli result in different neuronal and behavioral responses. This effect may depend on thalamo-cortical network mechanism directing sensory information to the cortex either through a first-order or higher-order thalamic relay nuclei. Using multichannel chronic recordings from the thalamo-cortical part of the somatosensory system of behaving rats, we have shown that in low arousal the information flow reaches primary sensory (S1) cortex mainly via first-order ventral posteromedial (VPM) nucleus and that a higher-order relay – posterior medial nucleus (PoM), receives this information later, via feedback input from S1. In contrast, during high arousal substantial part of the sensory information flow to S1 is passed also through the PoM nucleus. We propose that direct opening of peripheral inputs transmission through PoM follows the release of this nucleus from feed-forward inhibition exerted by zona incerta. This mechanism may serve to supply fast sensory information about salient stimuli not only to S1 but also, in parallel, to higher order sensory and motor cortices in order to facilitate behavioral reactions. Although such mechanism may lower the accuracy of detailed stimulus feature processing but may play a vital role during dangerous situations. Research was supported by the National Science Centre grant N N401 533040.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.15

Twórcy

autor

Kubik E.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland