A computational simulation of long-term synaptic potentiation inducing protocol processes with model of CA3 hippocampal microcircuit

• Autorzy: Swietlik D. , Bialowas J. , Cichonska D.
• Języki publikacji: EN

Abstrakty

EN

An experimental study of computational model of the CA3 region presents cognitive and behavioural functions the hippocampus. The main property of the CA3 region is plastic recurrent connectivity, where the connections allow it to behave as an auto-associative memory. The computer simulations showed that CA3 model performs efficient long-term synaptic potentiation (LTP) induction and high rate of sub-millisecond coincidence detection. Average frequency of the CA3 pyramidal cells model was substantially higher in simulations with LTP induction protocol than without the LTP. The entropy of pyramidal cells with LTP seemed to be significantly higher than without LTP induction protocol (p = 0.0001). There was depression of entropy, which was caused by an increase of forgetting coefficient in pyramidal cells simulations without LTP (R = –0.88, p = 0.0008), whereas such correlation did not appear in LTP simulation (p = 0.4458). Our model of CA3 hippocampal formation microcircuit biologically inspired lets you understand neurophysiologic data. (Folia Morphol 2018; 77, 2: 210–220)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2018
• Tom: 77
• Numer: 2
• Opis fizyczny: p.210–220,fig.,ref.

Twórcy

autor

Swietlik D.

• Intrafaculty College of Medical Informatics and Biostatistics, Medical University of Gdansk, Debinki 1, 80–211 Gdansk, Poland

autor

Bialowas J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Cichonska D.

• Department of Periodontology and Oral Mucosa Diseases, Medical University of Gdansk, Gdansk, Poland

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Identyfikatory

DOI

10.5603/FM.a2018.0042