Pharmacokinetics and pharmacodynamics of terguride following intramuscular administration in cows and goats

• Autorzy: Lapka R. , Krejci P. , Lidicky J. , Fruhaufova M. , Rezabek K.
• Języki publikacji: EN

Abstrakty

EN

Łapka R. Krejči, P. Lidický, J., Frühaufová, M. and Rezábek, K.: Pharmacokinetics and pharmacodynamlics of terguride following intramuscular administration in cows and goats. Acta physiol. pol., 1989, 40 (1): 139-144. The (pharmacokinetics of intramuscular terguride (transdihydrolisuride) was evaluated in a single-dose study in cows (doses 100, 62 and 31 μg/kg b.w.) and goats (dose 100 μg/kg b.w.). A radioreceptor assay was used to quantitative plasma terguride concentrations. The peak plasma concentrations of terguride were attained within 0.6 h of the drug administration and then decreased monoexponentially with half-life of 1.3 h (cows) and 2 h (goats). The pharmacokinetics of terguride in cows is nearly linear. Pharmacodynamics of terguride was expressed as reduction in plasma prolactin levels. Maximal decline in prolactin was observed 3-4 h following terguride administration and the effect lasted for about 24 h.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 1
• Opis fizyczny: p.139-144,fig.,ref.

Twórcy

autor

Lapka R.

• Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia

autor

Krejci P.

• Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

autor

Lidicky J.

• Research Institute of Biofactors and Veterinary Drugs, Prague, Czechoslovakia

autor

Fruhaufova M.

• Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia

autor

Rezabek K.

• Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia

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