Inhibitory effects of different medicinal plants on Candida albicans growth

• Autorzy: Tambur Z. , Cenic Milosevic D. , Mileusnic I. , Doder R. , Marjanovic M. , Miljkovic Selimovic B. , Kulisic Z. , Opacic D.
• Języki publikacji: EN

Abstrakty

EN

The objective of this study was to evaluate the in vitro antifungal properties of ethanol extracts and essential oils of medicinal plants from Serbia against Candida albicans (C. albicans) ATCC 10231. Ethanol extracts of fifteen plants were investigated, and their effects were compared with those of three different essential oils. The sensitivity of C. albicans to all plants was tested by the agar dilution method. The assay plates were estimated to contain 300, 150, 75, and 37.5 µg/ml of active extracts and 100, 50, 25, and 12.5 µg/ml of active essential oils. Inocula were applied to agar surfaces, giving approximately 106 cfu/ml of C. albicans. No inhibitory effects were observed for ethanol extracts of Hypericum perforatum and Salvia officinalis (MIC > 300 µg/ml). The most effective were the ethanol extract of Aesculus hippocastanum (MIC = 37.5 µg/ml) and the essential oil of Satureja kitaibelii (MIC = 12.5 µg/ml). Other plants showed MIC from 25 to 300 µg/ml. As far as we know, the inhibitory effects of these medicinal plants against the reference strain of C. albicans have not been commonly investigated in our country. Although the essential oil of Satureja kitaibelii shows strong activity against C. albicans, these results need clinical evaluation.

Słowa kluczowe

EN

inhibitory effect; medicinal plant; fungi; Candida albicans; fungal growth; antifungal activity

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2018
• Tom: 74
• Numer: 07
• Opis fizyczny: p.473-476,fig.,ref.

Twórcy

autor

Tambur Z.

• Faculty of Stomatology in Pancevo, 13000 Pancevo, Serbia
• Military Medical Academy, 11000 Belgrade, Serbia

autor

Cenic Milosevic D.

• Faculty of Stomatology in Pancevo, 13000 Pancevo, Serbia

autor

Mileusnic I.

• Faculty of Stomatology in Pancevo, 13000 Pancevo, Serbia

autor

Doder R.

• Military Medical Academy, 11000 Belgrade, Serbia

autor

Marjanovic M.

• Faculty of Stomatology in Pancevo, 13000 Pancevo, Serbia

autor

Miljkovic Selimovic B.

• Medical Faculty, University of Nis, 18000 Nis, Serbia

autor

Kulisic Z.

• Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia

autor

Opacic D.

• Military Medical Academy, 11000 Belgrade, Serbia

Bibliografia

• Alemu F., Andualem B.: Antimicrobial potentials of different solvent extracts of Justicia landonoides and Plantago lanceolata against standard and drug resistant human bacterial pathogens. Int. J. Microbiol. Res. 2014, 5, 6-18.
• Asha Devi S., Ganjewala D.: Antimicrobial activity of Acorus calamus (L.) rhizome and leaf extract. Acta Biol. Szeged 2009, 53, 45-49.
• Borugă O., Jianu C., Mişcă C., Goleţ I., Gruia A. T., Horhat F. G.: Thymus vulgaris essential oil: chemical composition and antimicrobial activity. J. Med. Life 2014, 7, 56-60.
• Brown G. D., Denning D. W., Levitz S. M.: Tackling human fungal infections. Science 2012, 336, 647.
• Calderone R. A., Clancy C. J. (ed): Candida and Candidiasis. ASM Press, Washington DC 2012.
• Candan F., Unlu M., Tepe B., Daferera D., Polissiou M., Sökmen A., Akpulath H. A.: Antioxidant and antimicrobial activity of the essential oil and methanolextracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J. Ethnopharmacol. 2003, 87, 215-220.
• Cardoso A. M. R., Cavalcanti Y. W., de Fátima Dantas de Almeida L., de Lima Pérez A. L. A., Padilha W. W. N.: Antifungal activity of plant-based tinctures on Candida. RSBO 2012, 9, 25-30.
• Cenić Milošević D., Tambur Z., Bokonjić D., Ivančajić S., Stanojković T., Grozdanić N., Juranić Z.: Antiproliferative effects of some medicinal plants on HeLa cells. Arch. Biol. Sci. 2013, 65, 65-70.
• Efstratiou E., Hussain A. I., Nigam P. S., Moore J. E., Ayub M. A., Rao J. R.: Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens. Complement Ther. Clin. Pract. 2012, 18, 173-176.
• Genena A. K., Hense H., Smânia Junior A., de Souza S. M.: Rosemary (Rosmarinus officinalis) – a study of the composition, antioxidant and antimicrobial activities of extracts obtained with supercritical carbon dioxide. Tecnol. Aliment. Campinas 2008, 28, 463-469.
• Juteau F., Jerkovic I., Masotti V., Milos M., Mastelic J., Bessiėre J. M., Viano J.: Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France. Planta Med. 2003, 69, 158-161.
• Leeja L., Thoppil J. E.: Antimicrobial activity of methanol extract of Origanum majorana L. (Sweet marjoram). J. Environ. Biol. 2007, 28, 145-146.
• Mayer F. L., Wilson D., Hube B.: Candida albicans pathogenicity mechanisms. Virulence 2013, 4, 119-128.
• Miladinović D., Miladinović Lj.: Antimicrobial activity of essential oil of sage from Serbia. Facta Universitatis 2000, 2, 97-100.
• Milosavljević P. N., Miladinović Lj.: Antibacterial activity and chemical composition of essential oil of Savory (Sature jakitaibelii Wierzb. ex Heuff). Proc. 6th Symp. on Flora of the Southeastern Serbia, Sokobanja 2000, p. 81-85.
• Mora C., Tittensor D. P., Adl S., Simpson A. G. B., Worm B.: How many species are there on Earth and in the ocean? PLoS Biol. 2011, e1001127.
• Lewis K., Ausubel F. M.: Prospects for plant‐derived antibacterials. Nat. Biotechnol. 2006, 12, 1504‐1507.
• Özbucak B. T., Akçin E. Ö., Ertürk Ö.: The change in ecological, anatomical and antimicrobiological properties of the medicinal plant Tilia rubra dc. subsp. caucasica (rupr.) v. engler along an elevational gradient. Pak. J. Bot. 2013, 45, 1735-1742.
• Peng C., Zhao S. Q., Zhang J., Huang G. Y., Chen L. Y., Zhao F. Y.: Chemical composition, antimicrobial property and microencapsulation of Mustard (Sinapis alba) seed essential oil by complex coacervation. Food Chem. 2014, 165C, 560-568.
• Roy A., Geetha R. V., Lakshmi T.: Evaluation of the antimycotic activity of aqueous and ethanolic extracts of Aesculus hippocastanum – an In vitro study. Int. J. Drug Dev. Res. 2011, 3, 335-338.
• Roy A., Geetha R. V., Lakshmi T.: In vitro evaluation of antibacterial activity of aqueous and ethanolic extracts of Aesculus hippocastanum on oral microbes. Asian J. Pharm. Clin. Res. 2011, 4, 90-92.
• Ruhnke M.: Candida and Candidiasis: Skin and mucous membrane infections. ASM Press, Washington DC 2002.
• Santoyo S., Cavero S., Jaime L., Ibañez E., Señoráns F. J., Reglero G.: Chemical composition and antimicrobial activity of Rosmarinus officinalis L. essential oil obtained via supercritical fluid extraction. J. Food Prot. 2005, 68, 790-795.
• Schuster D., Wolberg G.: Identification of bioactive natural products by pharmacophore-based virtual screening. Curr. Pharm. Des. 2010, 16, 1666-1681.
• Soleimanpour S., Sadat Sedighinia F., Safipour Afshar A., Zarif R., Ghazvini K.: Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study. Avicenna J. Phytomed. 2015, 5, 210-217.
• Stanković M. S., Stefanović O., Čomić Lj., Topuzović M., Radojević I., Solujić S.: Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species. Cent. Eur. J. Biol. 2012, 7, 664-671.
• Tocci N., Simonetti G., D’Auria F. D., Panella S., Palamara A. T., Ferrari F., Pasqua G.: Chemical composition and antifungal activity of Hypericum perforatum subsp. angustifolium roots from wild plants and plants grown under controlled conditions. Plant Biosystems 2013, 147, 557-562.
• Vatľák A., Kolesárová A., Vukovič N., Rovná K., Petrová J., Brindza J., Nōžková J.: Antimicrobial activity of medicinal plants against different strains of bacteria. J. Microbiol. Biotech. Food Sci. 2014, 3, 174-176.
• Zhang Z., Shiyou L. S., Lian X. Y.: An overview of genus Aesculus L. Ethnobotany, phytochemistry, and pharmacological activities. Pharm. Crops. 2010, 1, 24-51.

Identyfikatory

DOI

10.21521/mw.5995