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2015 | 74 | 2 |
Tytuł artykułu

Collagen types I and II distribution: a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised rabbit knee joints

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The objective of the present work was to study changes in collagen type I and type II distribution in the articular cartilage of immobilised and remobilised rabbit knee joints. Twenty-four adult male rabbits were divided into three groups. One of the groups was a control group with free movement. The right knee joints of animals of the other two groups were immobilised for 4 weeks, followed by a period of 10 weeks of remobilisation for animals of group 3. Collagen type I and type II in the articular cartilage of tibial medial condyle of the right knee joint were estimated immunohistochemically in all groups. A degenerative process was evident after 4 weeks of immobilisation of rabbit knee joint leading to a partial shift in the density of collagen composition from type II to type I. After a period of 10 weeks of remobilisation, regenerative processes, evidenced by a restoration of collagen type II to normal, proceeded on top of degenerative processes, evidenced by the significantly higher content of collagen type I compared with normal. The present study pointed to the importance of assessment of collagen distribution as a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised joints. (Folia Morphol 2015; 74, 2: 169–175)
Słowa kluczowe
Wydawca
-
Czasopismo
Rocznik
Tom
74
Numer
2
Opis fizyczny
p.169-175,fig.,ref.
Twórcy
  • Department of Anatomy and Embryology, College of Medicine, King Saud University, PO Box 2925(28), Riyadh 11461, Saudi Arabia,
  • Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
autor
  • Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  • Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt
autor
  • Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
autor
  • Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  • Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt
  • Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
autor
  • Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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