Wide band-gap oxide nanoparticles as potential drug carriers

• Autorzy: Lipinski W. , Kaszewski J. , Gajewski Z. , Godlewski M. , Godlewski M.M.
• Języki publikacji: EN

Abstrakty

EN

Recent decades have brought rapid development in the field of nanotechnology, which has led to applications of nanoparticles in many industries. Unique properties of nanoparticles and their biocompatibility increase their potential as drug carriers in drug-delivery systems. Prof. Marek Godlewski’s team from the Institute of Physics PAS has developed wide band-gap metal oxide nanoparticles doped with rare-earth metals for applications as fluorescent markers. The potential of those nanoparticles to cross the closed gut barrier after alimentary application has prompted their use in drug delivery systems. In this study, we show that after conjugation with a model bioactive substance, lectin (Phaseolus vulgaris), these nanoparticles retained their advantageous properties and, following oral administration (10 mg/ml in RO, 0.3 ml/mouse), entered a variety of organs in the mouse model. Internal organs collected at key time points were analysed under a scanning cytometer and a confocal microscope. The results show that the conjugation reduced, but did not completely abolish, the capacity of nanoparticles to penetrate physiological barriers (intestinal, blood-brain barrier) in the organism.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2017
• Tom: 73
• Numer: 10
• Opis fizyczny: p.657-660,fig.,ref.

Twórcy

autor

Lipinski W.

• Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 100, 02-797 Warsaw, Poland

autor

Kaszewski J.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-766 Warsaw, Poland
• Institute of Physics, Polish Academy of Sciences, Al.Lotnikow 32/46, 02-668 Warsaw, Poland

autor

Gajewski Z.

• Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 100, 02-797 Warsaw, Poland

autor

Godlewski M.

• Institute of Physics, Polish Academy of Sciences, Al.Lotnikow 32/46, 02-668 Warsaw, Poland

autor

Godlewski M.M.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-766 Warsaw, Poland

Bibliografia

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• Kiełbik P., Kaszewski J., Rosowska J., Wolska E., Witkowski B. S., Gralak M. A., Gajewski Z., Godlewski M., Godlewski M. M.: Biodegradation of the ZnO:Eu nanoparticles in the tissues of adult mouse after alimentary application. Nanomedicine: Nanotechnology, Biology, and Medicine 2016, doi: 10.1016/j.nano.2016.11.002.
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• Słońska A., Kaszewski J., Wolska-Kornio E., Witkowski B., Wachnicki Ł., Mijowska E., Karakitsou V., Gajewski Z., Godlewski M., Godlewski M. M.: Luminescent properties of ZrO2:Tb nanoparticles for applications in neuroscience. Optical Materials 2016, 59, 96-102.
• Wolska E., Kaszewski J., Kiełbik P., Grzyb J., Godlewski M. M., Godlewski M.: Rare earth activated ZnO nanoparticles as biomarkers. Optical Materials 2014, 36, 1655-1659.
• Yatsunenko S., Kaszewski J., Grzyb J., Pełech I., Godlewski M. M., Mijowska E., Narkiewicz U., Godlewski M.: Impact of yttria stabilization on Tb3+ intrashell luminescence efficiency in zirconium dioxide nanopowders. J. Phys.: Condens. Matter 2013, (25).
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Identyfikatory

DOI

10.21521/mw.5783