Somatostatin expressing cells in experience - dependent plasticity in the somatosensory cortex of adult mice

• Autorzy: Nowak K. , Liguz-Lecznar M. , Cybulska-Klosowicz A. , Zakrzewska R. , Kossut M.
• Języki publikacji: EN

Abstrakty

EN

Synaptic plasticity in the nervous system is associated with rapid state-dependent changes that require constant adaptation of the balance between excitation and inhibition. Increasing neuronal activity has been shown to stimulate the inhibitory system to preserve the excitation/inhibition homeostasis. Experimental data suggest an increased inhibitory GABA-ergic neurotransmission in brain structures involved in the learning process. Previously we have shown that classical conditioning involving stimulation of a row of facial vibrissae in adult mice results in an increased density of GABAergic interneurones and increased cortical expression of glutamic acid decarboxylase in granular layer of trained row representation. Also, we have found that parvalbumin containing subpopulation was not involved in the observed changes. From numerous subpopulations of GABAergic neurons, somatostatin (SST) containing cells seem to be likely involved in regulation of activity and plasticity of neuronal networks. To test this hypothesis we have used the sensory training protocol that was based on the classical conditioning where tactile stimulation of one row of sensory whiskers (CS) was paired with a tail shock (UCS). The training was continued for 3 consecutive days and lasted 10 min each day (40 trials). Cells expressing SST were assessed using stereology-based counting in both hemispheres in the barrel cortex. We have shown the substantial (22%) increase of SST-containing cells in the trained row representation. The result suggests that somatostatin is involved in learning induced changes of inhibitory cortical network. Supported by grant No. 2486/B/P01/2010/39 (M.K.) N N301 248639.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.45

Twórcy

autor

Nowak K.

• Department of Psychology, Warsaw School of Psychology and Humanities, Warsaw, Poland

autor

Liguz-Lecznar M.

• Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Cybulska-Klosowicz A.

• Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Zakrzewska R.

• Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Kossut M.

• Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

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