Warianty tytułu
Malondialdehyde content and the activity of the total antioxidant status in the aqueous humor of dogs with senile cataract
Języki publikacji
Abstrakty
Purpose: The aim of the study was to evaluate the content of malondialdehyde (MDA) and the activity of the total antioxidant status (TAS) in the aqueous humor of dogs with senile cataract without general conditions. Material and methods: The population examined consisted of 40 dogs of various breeds and sexes, aged 10-16 years, diagnosed with senile cataracts, which qualified for cataract surgery. Samples of the aqueous humor were collected at the beginning of the operation, after the opening of the anterior chamber. MDA luminescence spectra were determined with a Perkin-Elmer LS 30 by the method of Yagi. TAS was measured by a colorimetric reagent kit Randox Total Antioxidant Status. Results: Our results showed a significant increase in malondialdehyde (MDA) levels and a significantly lower activity of the total antioxidant status (TAS) in the aqueous humor of dogs with senile cataract compared to the control group. Conclusions: The results indicate an increased peroxidation of lipids and a local weakening of the defensive system in the aqueous humor of dogs with senile cataract. These results suggest that these conditions may have an impact on the development of age-related cataract, and are compatible with the free-radical theory of the development of senile cataract.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Opis fizyczny
s.636-637,tab.,bibliogr.
Twórcy
autor
- Katedra i Klinika Chorób Wewnętrznych Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Głęboka 30, 20-612 Lublin
autor
- Katedra i Klinika Chorób Wewnętrznych Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Głęboka 30, 20-612 Lublin
autor
- Katedra i Klinika Chorób Wewnętrznych Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Głęboka 30, 20-612 Lublin
Bibliografia
- 1. Ates N. A., Yildrim O., Tamer L., Unlu A., Ercan B., Muslu N., Kanik A., Hatungil R., Atik U.: Plasma catalase activity and malondialdehyde level in patients with cataract. Eye 2004, 18, 785-788.
- 2. Chang D., Zhang X., Rong S., Sha Q., Liu P., Han T., Pan H.: Serum antioxidative enzymes levels and oxidative stress products in age-related cataract patients. Oxid. Med. Cell. Longev. 2013, 587826.
- 3. Johns K. J.: Lens and Cataract. Basic and Clinical Science Course, The Found of American Academy of Ophtalmology. San Francisco 2000, 11, 66-68.
- 4. Kałużny J. J., Kałużny J.: Współczesne poglądy na patogenezę i możliwości profilaktyki zaćmy starczej. Pol. Merkuriusz Lek. 1997, 2, 76-78.
- 5. Kaur J., Kukreja S., Kaur A., Malhotra N., Kaur R.: The oxidative stress in cataract patients. J. Clin. Diagn. Res. 2012, 6, 1629-1632.
- 6. Kisic B., Miric D., Zoric L., Dragojevic I., Stolic A.: Role of lipid peroxidation in pathogenesis of senile cataract. Vojnosanit Pregl. 2009, 66, 371-375.
- 7. Kłos-Rola J., Zagórski Z.: Peroksydacja lipidów u chorych z zaćmą starczą. Klin. Oczna 2004, 106 Suppl., 416-418.
- 8. Micelli-Ferrari T., Vendemiale G., Gratagliano I., Boscia F., Arnese L., Altomare E., Cardia L.: Role of lipid peroxydation in the pathogenesis of myopic and senile cataract. Brit. J. Ophtalm. 1996, 80, 840-843.
- 9. Ofri R.: Soczewka, [w:] Maggs D. J., Miller P. E., Ofri R.: Okulistyka weterynaryjna Slattera. Elsevier, Wrocław 2008, s. 294.
- 10. Ottonello S., Foroni C., Carta A., Petrucco S., Maraini G.: Oxidative stress and age-related cataract. Ophthalmologica 2000, 214 (1), 78-85.
- 11. Sawada H., Fukuchi T., Abe H.: Oxidative stress markers in aqueous humor of patients with senile cataracts. Current Eye Research 2009, 34, 36-41.
- 12. Spector A.: Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995, 9, 1173-1182.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-c28c3a07-0823-4339-beea-ee9679149a31