Comparison of tumour morphology and structure from U87 and U118 glioma cells cultured on chicken embryo chorioallantoic membrane

• Autorzy: Jaworski S. , Sawosz E. , Grodzik M. , Kutwin M. , Wierzbicki M. , Wlodyga K. , Jasik A. , Reichert M. , Chwalibog A.
• Języki publikacji: EN

Abstrakty

EN

The objective of this study was the morphological and structural characterisation of glioblastoma multiforme grown in ovo. Glioma cells U87 and l M 18 were implanted in the chorioallantoic membrane (CAM) of chicken egg. After 10 days of incubation, tumours were resected for further analyses. Culturing two types of glioblastoma tumours from U87 and U118 cell lines has shown a number of differences in their morphology, histology, and ultrastructure. CAM assay proved to be a useful tool for studying glioblastoma growth. The model provides an excellent alternative to current rodent models and could serve as a preclinical screening assay for anticancer molecules. It might increase the speed and efficacy of the development of new drugs for the treatment of glioblastoma.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2013
• Tom: 57
• Numer: 4
• Opis fizyczny: p.593-598,fig.,ref.

Twórcy

autor

Jaworski S.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Sawosz E.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Grodzik M.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Kutwin M.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Wierzbicki M.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Wlodyga K.

• Faculty of Animal Science, Division of Nanobiotechnology, Warsaw University of Life Science, 02- 786 Warsaw, Poland

autor

Jasik A.

• Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Reichert M.

• Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Chwalibog A.

• Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark

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Identyfikatory

DOI

10.2478/bvip-2013-0101