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2014 | 73 | 4 |
Tytuł artykułu

Thyroid lymphoepithelial nodule

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology. A 56-year-old woman presented with a thyroid nodule increasing in size. Thyroid function was normal. On the surgical resection specimen, in addition to a 2-cm follicular adenoma, there was, at distance, a 0.5-cm solid nodule with lymphoepithelial morphology, without Hassal’s corpuscles or calcifications. On immunohistochemistry, the epithelial component was cytokeratin 5/6 positive and very focally cytokeratin 7 positive, the immunophenotype of the lymphoid tissue confirming the benign nature. The diagnosis of thyroid benign lymphoepithelial nodule was proposed. In conclusion, recognition of thyroid solid benign lymphoepithelial nodules is important since they can be misdiagnosed with other thyroid micronodule types including carcinoma, primary or metastatic. (Folia Morphol 2014; 73, 4: 507–509)
Słowa kluczowe
Wydawca
-
Czasopismo
Rocznik
Tom
73
Numer
4
Opis fizyczny
p.507-509,fig.,ref.
Twórcy
  • Service d’Anatomie Pathologique, APHP GHU Avicenne, Bobigny, France
  • Universite Paris Nord Sorbonne Cite, Bobigny, France
autor
  • Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, United States
Bibliografia
  • 1. Carney JA (1989) Thyroid cysts. Am J Surg Pathol, 13: 1072–1074.
  • 2. Choi CJ, Choi SW, Cho JG, Woo JS (2010) Bilateral lymphoepithelial cysts of the thyroid gland. Thyroid, 20: 111–113.
  • 3. Delabie J, De Wolf-Peeters C, Cappelle L, Van Damme B, Desmet V (1990) Branchial cleftlike cysts of the thyroid. Am J Surg Pathol, 14: 1165–1167.
  • 4. Ellis GL, Auclair PL (1996) Tumors of the Salivary Glands. AFIP fascicle 17, 3rd series. Armed Forces Institute of Pathology, Washington DC.
  • 5. Handra-Luca A (2014) Subangulomaxillary cyst containing vestigeal remnants with thymic and parathyroid differentiation in an adult HIV1-positive patient. Int J Surg Pathol, 22: 93–95.
  • 6. Khan A (2009) Surgical pathology of endocrine and neuroendocrine tumors. Humana Press, New York.
  • 7. Kreft A, Hansen T, Kirkpatrick CJ (2005) Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer. Virchows Arch, 447: 9–11.
  • 8. Louis DN, Vickery AL Jr, Rosai J, Wang CA (1989) Multiple branchial cleft-like cysts in Hashimoto’s thyroiditis. Am J Surg Pathol, 13: 45–49.
  • 9. Matias-Guiu X, Esquius J (1991) Lymphoepithelial lesion in the thyroid. A non-specific histological finding. Pathol Res Pract, 187: 296–300.
  • 10. Mooij P1, de Wit HJ, Drexhage HA (1994) A high iodine intake in Wistar rats results in the development of a thyroid-associated ectopic thymic tissue and is accompanied by a low thyroid autoimmune reactivity. Immunology, 81: 309–316.
  • 11. Rosai J, Carcangiu ML, DeLellis RA (1992) Tumors of the thyroid gland. AFIP fascicle 5. 3rd series. Armed Forces Institute of Pathology, Washington DC.
  • 12. Rosai J (2011) Rosai and Ackerman’s surgical pathology. 10th Ed. Elsevier, Philadelphia.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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