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Wójcicki, J. Samochowiec, L. and Kadłubowska D.: Inhibition of ethanol- -induced changes in rats by Padma 28. Acta physiol, pol., 1989, 40 (4): 387-392. In male Wistar rats the protective effect of Padma 28 against changes induced by prolonged treatment with ethyl alcohol was investigated. Exposure of the animals to prolonged ethyl alcohol consumption caused a significant liner ease in AspAT (by 32%) AlAT (by 50%) and alkaline phosphatase (by 372%) activities as well as ian increase in the levels of bilirubin (by 98%) and lipids in the blood serum and lipids in the liver homogenate. Padma 28 administration was found to exert a protective action against these changes: a significant reduction of blood total lipid, triacylglycerol, total cholesterol and bilirubin concentrations as well as in the activity of the liver enzymes was observed.
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p.387-392,ref.
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- Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland
autor
- Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland
autor
- Institute of Pharmacology and Toxicology, School of Medicine, Szczecin, Poland
Bibliografia
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- 15. Samochowiec, L., Janiec, W., Wójcicki, J. (1986) Influence of Padma 28 on the oxidation of palmitic acid-l-¹⁴C to ¹⁴CO₂. Herba Polon. 32. 183-4186.
- 16. Samochowiec, L., Wójcicki, J. (1987) Effect of Padma 28 on lipid endoperoxides formation. Herba Polon. 33. 219-222.
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