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Abstrakty
Activity of cancer procoagulant (CP) was studied in blood serum of 90 patients with cancer of lung, breast, oesophagus and colorectum, and of 15 healthy people. The activity of CP was determined by the coagulation method. Sera of patients with cancer showed higher mean activity of CP than sera of healthy control. Of the 90 cancer patients 78 were identified correctly by this test as having cancer (sensitivity 85%). In the case of lung and colorectal cancers the higher CP activity was observed the more advanced was the clinical stage of cancer, and the test was positive in 100%. After radical removal of malignant tumor of lung, decreased CP activity was found.
Twórcy
autor
- Medical Academy in Bialystok, Ogrodowa 12, 15-027 Bialystok, Poland
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Bibliografia
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- 2. Gordon, S.G. (1994) Cancer procoagulant. Methods Enzymol. 244, 568-583.
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- 4. Gordon, S.G. & Benson, B. (1989) Analysis of serum cancer procoagulant activity and its possible use as a tumor marker. Thrombos. Res. 56, 431-440.
- 5. Kozwich, D.L., Kramer, L.C., Mielicki, W.P., Fotopoulos, S.S. & Gordon, S.G. (1994) Application of cancer procoagulant as an early detection tumor marker. Cancer 74, 1367-1376.
- 6. Falanga, A. & Gordon, S.G. (1985) Comparison of properties of cancer procoagulant and human amnion-chorion procoagulant. Bio- chim. Biophys. Acta 831, 161-165.
- 7. Gordon, S.G. & Cross, B.A. (1990) An enzyme- linked immunosorbent assay for cancer procoagulant and its potential as a new tumor marker. Cancer Res. 50, 6229-6234.
- 8. Mielicki, W. & Wierzbicki, R. (1990) Cancer procoagulant in serum of rats during development of experimental epithelioma. Int. J. Cancer 45, 125-126.
- 9. Donati, M.B., Falanga, A., Consonni, R., Ale- sio, M.G., Bassan, R., Buelli, M., Borin, L., Catani, L., Pogliani, E. & Gugliotta, L. (1990) Cancer procoagulant in acute non lymphoid leukemia: Relationship of enzyme detection to disease activity. Thrombos. Haemostas. 64, 11-16.
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Bibliografia
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